Miglitol

Generic Name
Miglitol
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C8H17NO5
CAS Number
72432-03-2
Unique Ingredient Identifier
0V5436JAQW
Background

Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.

Miglitol should be taken at the start of a meal for maximal effect and the effect will depend on the amount of poly and oligosaccharides in the diet. Miglitol inhibits alpha-glucosidase, making less sugars available for digestion and reducing postprandial hyperglycemia.

Unlike other drugs of the same class, miglitol is not metabolized and the unmetabolized drug is excreted by the kidneys.

Indication

For use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone.

Associated Conditions
Type 2 Diabetes Mellitus
Associated Therapies
-

A Study to Assess Drug-Drug Interaction Between ASP1941 and Miglitol

First Posted Date
2010-04-08
Last Posted Date
2010-06-09
Lead Sponsor
Astellas Pharma Inc
Target Recruit Count
30
Registration Number
NCT01099839

Double-Blind Study of Miglitol in Japanese With type2 Diabetes

Phase 3
Completed
Conditions
First Posted Date
2006-09-27
Last Posted Date
2006-09-27
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00380822

Double-Blind Trial of Miglitol in Type 2 Diabetic Patients Treated With Biguanide

Phase 3
Completed
Conditions
First Posted Date
2006-06-07
Last Posted Date
2008-10-10
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00334399

Open Trial of Miglitol in Type 2 Diabetic Patients Treated With Biguanide

Phase 3
Completed
Conditions
First Posted Date
2006-06-07
Last Posted Date
2008-10-10
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00334503

Double-Blind Trial of Miglitol in Type 2 Diabetic Patients With Insulin Treatment

Phase 3
Completed
Conditions
First Posted Date
2005-09-21
Last Posted Date
2006-09-21
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00213070

Open Trial of Miglitol in Type 1 Diabetic Patients With Insulin Treatment

Phase 3
Completed
Conditions
First Posted Date
2005-09-21
Last Posted Date
2006-09-21
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00213109

Effects of Miglitol on Daily Plasma Glucose in type2 Diabetes Treated With Insulin

Phase 3
Completed
Conditions
First Posted Date
2005-09-21
Last Posted Date
2006-09-28
Lead Sponsor
Sanwa Kagaku Kenkyusho Co., Ltd.
Registration Number
NCT00213122
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