Donidalorsen
- Generic Name
- Donidalorsen
Donidalorsen Expanded Access Program for Patients With Hereditary Angioedema
- Conditions
- Hereditary Angioedema
- First Posted Date
- 2024-05-16
- Last Posted Date
- 2024-05-16
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Registration Number
- NCT06415448
A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)
- First Posted Date
- 2022-05-26
- Last Posted Date
- 2024-11-12
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Target Recruit Count
- 144
- Registration Number
- NCT05392114
- Locations
- 🇬🇧
Ionis Investigative Site, London, United Kingdom
OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE)
- First Posted Date
- 2021-12-01
- Last Posted Date
- 2025-03-06
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Target Recruit Count
- 91
- Registration Number
- NCT05139810
- Locations
- 🇬🇧
Ionis Investigative Site, London, United Kingdom
Antisense Therapy to Block the Kallikrein-kinin Pathway in COVID-19
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2022-09-22
- Lead Sponsor
- Hospital do Coracao
- Target Recruit Count
- 111
- Registration Number
- NCT04549922
- Locations
- 🇧🇷
Hospital São Paulo - UNIFESP, São Paulo, Brazil
🇧🇷Hospital Naval MarcÃlio Dias, Rio De Janeiro, Brazil
🇧🇷BP-A Beneficiência Portuguesa de São Paulo, São Paulo, Brazil
An Extension Study of Donidalorsen (IONIS-PKK-LRx) in Participants With Hereditary Angioedema
- First Posted Date
- 2020-03-13
- Last Posted Date
- 2025-03-24
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Target Recruit Count
- 20
- Registration Number
- NCT04307381
- Locations
- 🇳🇱
Ionis Investigative Site, Amsterdam, Netherlands
A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as IONIS-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema
- First Posted Date
- 2019-07-24
- Last Posted Date
- 2023-04-03
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Target Recruit Count
- 23
- Registration Number
- NCT04030598
- Locations
- 🇺🇸
Bernstein Clinical Research Center, LLC, Cincinnati, Ohio, United States
🇺🇸Medical Research of Arizona, Scottsdale, Arizona, United States
🇺🇸Penn State Hershey Medical Center, Hershey, Pennsylvania, United States
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Donidalorsen (IONIS-PKK-LRx) Administered Subcutaneously to Healthy Volunteers
- First Posted Date
- 2017-08-28
- Last Posted Date
- 2022-08-04
- Lead Sponsor
- Ionis Pharmaceuticals, Inc.
- Target Recruit Count
- 32
- Registration Number
- NCT03263507
- Locations
- 🇨🇦
Ionis Investigative Site, Toronto, Ontario, Canada
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