Povidone-iodine

Generic Name: Povidone-iodine

Brand Names: Betadine, Kenalog, Marbeta, Marcaine, P-Care M, P-Care MG, P-care, P-care X, Summer's Eve Medicated

Drug Type: Small Molecule

CAS Number: 25655-41-8

Unique Ingredient Identifier: 85H0HZU99M

Background: Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. During in vitro testing to demonstrate anti-bacterial activity it was found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Indication: For topical application in the treatment and prevention of infection in wounds.

Associated Conditions: Skin Infections

Associated Therapies: Skin disinfection, Antiseptic skin preparation therapy, Irrigation of the ocular surface therapy, Prepping of the periocular region

Clinical Trials

Povidone Iodine Versus Normal Saline in Preoperative Vaginal Cleansing Before Caesarean Section

Not Applicable

Completed

Conditions: Povidone Iodine
Normal Saline
Pre-operative

Interventions: Drug: Povidone-Iodine
Drug: Normal Saline

First Posted Date: 2025-04-30

Last Posted Date: 2025-05-02

Lead Sponsor: Federal Teaching Hospital Abakaliki

Target Recruit Count: 224

Registration Number: NCT06950229

Locations: 🇳🇬
Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi, Nigeria

Vaginal Cleansing With Chlorhexidine Versus Iodine for Prevention of Endometritis

Not Applicable

Completed

Conditions: Endometritis
Vaginal Cleansing
Post Caesarean

Interventions: Drug: Chlorhexidine Gluconate
Drug: Povidone-Iodine

First Posted Date: 2025-04-20

Last Posted Date: 2025-05-01

Lead Sponsor: Federal Teaching Hospital Abakaliki

Target Recruit Count: 239

Registration Number: NCT06936475

Locations: 🇳🇬
Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi, Nigeria

Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion

Phase 4

Recruiting

Conditions: Spinal Fusion

Interventions: Biological: 10% Povidone-Iodine Arm
Procedure: Saline Arm

First Posted Date: 2024-12-20

Last Posted Date: 2025-01-13

Lead Sponsor: Akron Children's Hospital

Target Recruit Count: 60

Registration Number: NCT06744907

Locations: 🇺🇸
Akron Children's Hospital, Akron, Ohio, United States

Topical 10% Povidone-Iodine in Preventing White Spots

Phase 2

Recruiting

Conditions: White Spot Lesions
Gingival Inflammation and Bleeding

Interventions: Drug: Placebo
Drug: Povidone-iodine solution

First Posted Date: 2024-09-27

Last Posted Date: 2024-09-27

Lead Sponsor: University of Washington

Target Recruit Count: 80

Registration Number: NCT06616207

Locations: 🇺🇸
University of Washington, School of Dentistry Department of Orthodontics, 1959 NE Pacific St. Health Sciences Center, Seattle, Washington, United States