Overview
Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP receptor, which is believed to play a critical role in migraine . In particular, erenumab-aooe is a human immunoglobulin G2 monoclonal antibody that has high affinity binding to the CGRP receptor . The antibody is produced utlilizing recombinant DNA technology in Chinese hamster ovary cells . It is composed of 2 heavy chains, each containing 456 amino acids, and 2 light chains of the lambda subclass, each containing 216 amino acids, with an approximate molecular weight of 150 kDa .
Indication
Erenumab is indicated for the preventative treatment of migraine in adults .
Associated Conditions
- Migraine
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2020/04/24 | N/A | UNKNOWN | |||
2020/03/11 | Phase 2 | Terminated | |||
2020/03/03 | Phase 4 | Completed | |||
2020/02/12 | Phase 4 | Completed | |||
2020/02/05 | Phase 4 | Completed | |||
2020/01/31 | Phase 4 | Completed | David Jang, M.D. | ||
2019/11/27 | Phase 1 | Completed | |||
2019/11/05 | N/A | Completed | Clinique des Céphalées de Montréal | ||
2019/10/03 | Phase 3 | Withdrawn | |||
2019/09/23 | Phase 2 | Completed |
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