Famotidine

Generic Name: Famotidine

Brand Names: Duexis, Duo Fusion, Fluxid, Good Sense Acid Reducer, Pepcid, Pepcid Complete, Zantac Reformulated Aug 2022

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₅N_₇O_₂S_₃

CAS Number: 76824-35-6

Unique Ingredient Identifier: 5QZO15J2Z8

Background: Famotidine is a competitive histamine-2 (H) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H receptor antagonists, famotidine displays high selectivity to...

Indication: Famotidine is indicated in pediatric and adult patients (with the bodyweight of 40 kg and above) for the management of active duodenal ulcer (DU), active gastric ulcer, symptomatic non-erosive gastroesophageal reflux disease (GERD), and erosive esophagitis due to GERD, diagnosed by biopsy.
...

Associated Conditions: Chronic Back Pain, Duodenal Ulcer, Erosive Esophagitis, Extra-Articular Rheumatism, Gastritis, Heartburn, Helicobacter Pylori Infection, Multiple Endocrine Neoplasia, Muscle Spasms, Nonspecific Pain Post Traumatic Injury, Osteoarthritis (OA), Postoperative pain, Stress Ulcers, Symptomatic Non-erosive Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Active Gastric ulcer, Acute Duodenal Ulcers, Gastrointestinal ulceration, Pathological hypersecretory conditions

Associated Therapies: -

Clinical Trials

Proton Pump Inhibitors and Risk of Community-acquired Pneumonia

Completed

Conditions: Gastroesophageal Reflux Disease (GERD)
Community-acquired Pneumonia

Interventions: Drug: esomeprazole
Drug: cimetidine
Drug: omeprazole
Drug: ranitidine
Drug: pantoprazole
Drug: famotidine
Drug: lansoprazole
Drug: nizatidine
Drug: rabeprazole
Drug: niperotidine
Drug: roxatidine
Drug: ranitidine bismuth citrate
Drug: lafutidine
Drug: cimetidine combinations
Drug: famotidine combinations

First Posted Date: 2015-09-22

Last Posted Date: 2015-09-22

Lead Sponsor: Canadian Network for Observational Drug Effect Studies, CNODES

Target Recruit Count: 4238504

Registration Number: NCT02555852

Locations: 🇨🇦
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada

Safety Study of BMS-986165 in Healthy Subjects and to Treat Psoriasis

Phase 1

Completed

Conditions: Healthy Subjects

Interventions: Drug: BMS-986165
Drug: Interferon alpha-2a recombinant
Drug: Famotidine
Other: Placebo

First Posted Date: 2015-08-27

Last Posted Date: 2016-12-28

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 140

Registration Number: NCT02534636

Locations: 🇦🇺
Local Institution, Melbourne, Victoria, Australia

Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)

Not Applicable

Completed

Conditions: Post-Operative Nausea and Vomiting
Breast Cancer

Interventions: Procedure: Electrical Stimulation
Drug: Zofran
Drug: Dexamethasone
Drug: Phenergan
Drug: Pepcid
Behavioral: Questionnaire

First Posted Date: 2015-06-16

Last Posted Date: 2024-12-16

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 187

Registration Number: NCT02473042

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Anesthetics in Rhytidoplasty - A Comparison Study

Not Applicable

Completed

Conditions: Rhytidoplasty

Interventions: Drug: clonidine
Drug: glycopyrrolate
Drug: propofol
Drug: scopolamine
Drug: ketamine
Drug: midazolam
Device: ondansetron
Drug: marcaine
Drug: lidocaine
Drug: metoclopramide
Drug: famotidine
Drug: desflurane
Drug: sevoflurane

First Posted Date: 2015-04-07

Last Posted Date: 2015-04-07

Lead Sponsor: Mercy Facial Plastic Surgery Center

Target Recruit Count: 30

Registration Number: NCT02410460

Locations: 🇺🇸
Mercy Facial Plastic Surgery Center, Springfield, Missouri, United States

Histamine Glutamate Antagonism in Stroke

Phase 2

Completed

Conditions: Acute Cerebrovascular Accident
Cerebral Edema

Interventions: Drug: Pantoprazole
Drug: Diphenhydramine
Drug: Famotidine
Drug: Dextromethorphan

First Posted Date: 2014-05-20

Last Posted Date: 2015-12-15

Lead Sponsor: University of Florida

Target Recruit Count: 3

Registration Number: NCT02142712

Locations: 🇺🇸
Shands Hospital at University of Florida, Gainesville, Florida, United States

Study Of Three Different Stomach Acid Reducing Agents When Given With Palbociclib (PD-0332991) And Food

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: palbociclib commercial free base
Drug: antacid
Drug: famotidine
Drug: rabeprazole

First Posted Date: 2014-03-27

Last Posted Date: 2014-06-19

Lead Sponsor: Pfizer

Target Recruit Count: 27

Registration Number: NCT02097329

Locations: 🇺🇸
Pfizer Investigational Site, New Haven, Connecticut, United States

Famotidine in Schizophrenia

Phase 2

Conditions: Schizophrenia

Interventions: Drug: Famotidine
Drug: Placebo

First Posted Date: 2013-09-19

Last Posted Date: 2015-04-14

Lead Sponsor: Jesper Ekelund

Target Recruit Count: 140

Registration Number: NCT01946295

Locations: 🇫🇮
Helsinki University, Helsinki, Finland
🇸🇪
Norra Stockholms Psykiatri, Stockholm County Council, Stockholm, Sweden
🇫🇮
Social services and Healthcare, City of Helsinki, Helsinki, Finland

and more 3 locations