Nafcillin

Generic Name: Nafcillin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₂N_₂O_₅S

CAS Number: 147-52-4

Unique Ingredient Identifier: 4CNZ27M7RV

Background: A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicill...

Indication: Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.

Associated Conditions: Bacterial Infections

Associated Therapies: -

Clinical Trials

DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

Phase 2

Completed

Conditions: Staphylococcal Bacteraemia

Interventions: Drug: Dalbavancin
Drug: Cefazolin
Drug: Daptomycin
Drug: Nafcillin
Drug: Oxacillin
Drug: Vancomycin

First Posted Date: 2021-03-01

Last Posted Date: 2024-12-10

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 200

Registration Number: NCT04775953

Locations: 🇺🇸
Corewell Health - Infectious Disease, Royal Oak, Michigan, United States
🇺🇸
University of Alabama Hospital - Infectious Diseases, Birmingham, Alabama, United States
🇺🇸
University of California Davis Medical Center - Internal Medicine - Infectious Disease, Sacramento, California, United States

and more 21 locations

Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Phase 2

Completed

Conditions: Osteomyelitis

Interventions: Drug: daptomycin
Drug: vancomycin
Drug: teicoplanin
Drug: nafcillin
Drug: oxacillin
Drug: flucloxacillin

First Posted Date: 2007-01-30

Last Posted Date: 2018-01-31

Lead Sponsor: Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Target Recruit Count: 75

Registration Number: NCT00428844

Locations: 🇺🇸
Dartmouth-Hitchcock Medical center, Lebanon, New Hampshire, United States
🇷🇺
Federal Healthcare Institute "Novosibirsk Scientific Research Institute of Traumatology and Orthopedy Rosmeditechnology", Novosibirsk, Russian Federation
🇺🇸
Gundersen Clinic, LTD, La Crosse, Wisconsin, United States

and more 23 locations

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