Overview
Dotatate gallium (Ga-68) is a somatostatin-2 receptor analog which is radiolabeled with gallium 68 as a positron-emitting radioisotope. Ga-68 dotatate has a high affinity for somatostatin-2 receptor and it is rapidly excreted from the nontarget sites which gives it an ideal candidate for imaging neuroendocrine tumors. Dotatate gallium (Ga-68) explotes its ability to detect somatostatin receptor scintigraphy and this characteristic tends to change with tumor grade which gives Ga-68 dotate a high diagnostic value. Dotatate gallium 68 was developed by Advanced Accelerator Applications USA, Inc. and FDA approved in June 1, 2016.
Background
Dotatate gallium (Ga-68) is a somatostatin-2 receptor analog which is radiolabeled with gallium 68 as a positron-emitting radioisotope. Ga-68 dotatate has a high affinity for somatostatin-2 receptor and it is rapidly excreted from the nontarget sites which gives it an ideal candidate for imaging neuroendocrine tumors. Dotatate gallium (Ga-68) explotes its ability to detect somatostatin receptor scintigraphy and this characteristic tends to change with tumor grade which gives Ga-68 dotate a high diagnostic value. Dotatate gallium 68 was developed by Advanced Accelerator Applications USA, Inc. and FDA approved in June 1, 2016.
Indication
Dotatate gallium 68 is one of the most prominent radiopharmaceuticals used in imaging with positron emission tomography. It binds to the somatostatin-2 receptor which is usually overexpressed in many neuroendocrine tumors in both adult and pediatric patients. The neuroendocrine tumors are bening or malignant tumors produced in the hormone producing cells of the neuroendocrine system.
Associated Conditions
- Neuroendocrine Tumors
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/09/25 | Phase 3 | Recruiting | University Hospital, Grenoble | ||
2024/06/28 | Phase 1 | Not yet recruiting | |||
2024/05/24 | Phase 1 | Recruiting | |||
2023/10/19 | Phase 3 | Recruiting | |||
2023/08/14 | Phase 1 | Completed | |||
2022/01/10 | Phase 2 | UNKNOWN | Central Hospital, Nancy, France | ||
2021/10/06 | Early Phase 1 | Recruiting | |||
2020/12/30 | Phase 1 | UNKNOWN | |||
2020/10/30 | Phase 1 | Recruiting | |||
2019/08/28 | N/A | Recruiting |
FDA Approved Products
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No FDA products found
No FDA products found for this drug
EMA Approved Products
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No EMA products found for this drug
HSA Approved Products
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No HSA products found for this drug
NMPA Approved Products
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No NMPA products found for this drug
PPB Approved Products
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TGA Approved Products
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No TGA products found
No TGA products found for this drug