Neostigmine

Generic Name: Neostigmine

Brand Names: Bloxiverz, Prevduo, Prostigmin

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₉N_₂O_₂

CAS Number: 59-99-4

Unique Ingredient Identifier: 3982TWQ96G

Background: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Indication: Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.

Associated Conditions: Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony

Associated Therapies: -

Clinical Trials

Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

Phase 1

Not yet recruiting

Conditions: Post-Dural Puncture Headache

Interventions: Drug: normal Saline
Drug: Neostigmine
Drug: Ketorolac

First Posted Date: 2024-12-11

Last Posted Date: 2024-12-11

Lead Sponsor: Assiut University

Target Recruit Count: 330

Registration Number: NCT06729047

Locations: 🇪🇬
Faculty of medicine, Assiut University, Assiut, Egypt,, Assiut, Egypt

Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

Completed

Conditions: Gastric Reflux

Interventions: Drug: Neostigmine

First Posted Date: 2024-11-13

Last Posted Date: 2024-11-13

Lead Sponsor: Zulekha Hospitals

Target Recruit Count: 3

Registration Number: NCT06687187

Locations: 🇪🇬
Al-Azhar faculty of medicine, Cairo, Egypt

Sugammadex on Laparoscopic Bariatric Surgery

Not Applicable

Not yet recruiting

Conditions: Laparoscopic Bariatric Surgery
Sugammadex

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2024-11-07

Last Posted Date: 2024-11-07

Lead Sponsor: Shanxi Bethune Hospital

Target Recruit Count: 60

Registration Number: NCT06678451

MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section

Phase 2

Not yet recruiting

Conditions: Cesarean Section

Interventions: Procedure: transversus abdominis plane (TAP) block in cesarean section
Drug: Magnesium sulfate
Drug: Neostigmine

First Posted Date: 2024-07-22

Last Posted Date: 2024-07-22

Lead Sponsor: Assiut University

Target Recruit Count: 68

Registration Number: NCT06513013

Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries

Early Phase 1

Completed

Conditions: Vitreoretinal Surgeries
Local Anesthesia

Interventions: Drug: Neostigmine
Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2024-07-15

Last Posted Date: 2024-07-15

Lead Sponsor: Ain Shams University

Target Recruit Count: 81

Registration Number: NCT06501352

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis

Not Applicable

Recruiting

Conditions: Reversal of Neuromuscular Blockade

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2024-05-31

Last Posted Date: 2024-06-27

Lead Sponsor: Beijing Tongren Hospital

Target Recruit Count: 64

Registration Number: NCT06436768

Locations: 🇨🇳
Beijing tongren Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China

The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery

Not Applicable

Not yet recruiting

Conditions: Neuromuscular Blockade

Interventions: Drug: SUGAMMADEX SODIUM 100 Mg in 1 mL
Drug: Neostigmine

First Posted Date: 2024-03-28

Last Posted Date: 2024-03-28

Lead Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Target Recruit Count: 80

Registration Number: NCT06334562

Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment

Not Applicable

Conditions: Anesthesia Intubation Complication

Interventions: Device: Train of four monitoring device intraoperative
Drug: Neostigmine
Procedure: Air chalenge prior to extubation
Device: Train of Four monitoring device in recovery room

First Posted Date: 2024-02-23

Last Posted Date: 2024-05-10

Lead Sponsor: University of Surabaya

Target Recruit Count: 240

Registration Number: NCT06275542

Locations: 🇮🇩
Sardjito General Hospital, Yogyakarta, Indonesia

Neostigmine Versus Sugammadex on Renal Functions

Phase 4

Active, not recruiting

Conditions: Sugammadex
Neostigmine

Interventions: Drug: Sugammadex
Drug: Neostigmine

First Posted Date: 2023-10-13

Last Posted Date: 2023-10-13

Lead Sponsor: Menoufia University

Target Recruit Count: 64

Registration Number: NCT06081738

Locations: 🇪🇬
Menoufia University Hospitals, Shibīn Al Kawm, Menoufia, Egypt

Regional Anaesthesia

Not Applicable

Completed

Conditions: Anesthesia, Obstetric

Interventions: Drug: DEXMEDETOMIDINE
Drug: Neostigmine
Drug: Bupivacaine

First Posted Date: 2023-09-26

Last Posted Date: 2023-09-26

Lead Sponsor: Reham Ali Abdelhaleem Abdelrahman

Target Recruit Count: 54

Registration Number: NCT06055101

Locations: 🇪🇬
Reham Ali Abdelrahman, Cairo, Egypt

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