Neostigmine
- Generic Name
- Neostigmine
- Brand Names
- Bloxiverz, Prevduo, Prostigmin
- Drug Type
- Small Molecule
- Chemical Formula
- C12H19N2O2
- CAS Number
- 59-99-4
- Unique Ingredient Identifier
- 3982TWQ96G
- Background
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
- Indication
Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.
- Associated Conditions
- Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony
- Associated Therapies
- -
Investigation of Sugammadex in Outpatient Urological Procedures
- Conditions
- Interventions
- First Posted Date
- 2017-05-03
- Last Posted Date
- 2020-09-22
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 54
- Registration Number
- NCT03138967
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Comparing Reversal With Neostigmine and Sugammadex in Paediatric
- Conditions
- Interventions
- First Posted Date
- 2017-05-02
- Last Posted Date
- 2017-05-02
- Lead Sponsor
- Universiti Sains Malaysia
- Target Recruit Count
- 80
- Registration Number
- NCT03137290
- Locations
- 🇲🇾
University of Science Malaysia Hospital, Kubang Kerian, Kelantan, Malaysia
Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery
- First Posted Date
- 2017-04-13
- Last Posted Date
- 2022-04-01
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 40
- Registration Number
- NCT03112993
- Locations
- 🇺🇸
University on Missouri Hospital, Columbia, Missouri, United States
Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
- Conditions
- Interventions
- First Posted Date
- 2017-04-12
- Last Posted Date
- 2019-04-29
- Lead Sponsor
- West Virginia University
- Target Recruit Count
- 84
- Registration Number
- NCT03111121
- Locations
- 🇺🇸
WVU Healthcare Ruby Memorial Hospital, Morgantown, West Virginia, United States
Comparison the Postoperative Quality of Recovery Between Neostigmine and Sugammadex in Elderly Patients Undergoing Trans Pars Plana Vitrectomy With General Anesthesia -Randomized Controlled Trial-
- Conditions
- Interventions
- First Posted Date
- 2017-04-11
- Last Posted Date
- 2017-11-17
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 90
- Registration Number
- NCT03108989
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Seoul, Korea, Republic of
Deep Neuromuscular Block for Laparoscopic Surgery
- Conditions
- Interventions
- First Posted Date
- 2017-01-27
- Last Posted Date
- 2020-04-22
- Lead Sponsor
- University of Melbourne
- Target Recruit Count
- 350
- Registration Number
- NCT03034577
- Locations
- 🇦🇺
Melbourne Health, Parkville, Victoria, Australia
🇦🇺Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia
🇦🇺The Royal Womens Hospital, Parkville, Victoria, Australia
Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia
- First Posted Date
- 2017-01-16
- Last Posted Date
- 2019-01-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT03021772
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
Cerebral Oxygenation and Metabolism After Reversal Of Rocuronium: Comparison Between Sugammadex Versus Neostigmine
- Conditions
- Interventions
- First Posted Date
- 2016-10-25
- Last Posted Date
- 2018-10-19
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 40
- Registration Number
- NCT02944175
Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals
- First Posted Date
- 2016-09-26
- Last Posted Date
- 2019-09-12
- Lead Sponsor
- Jakob Louis Thomsen
- Target Recruit Count
- 30430
- Registration Number
- NCT02914119
- Locations
- 🇩🇰
Herlev Hospital, Herlev, Denmark
Quality of Recovery After Reversal With Neostigmine or Sugammadex.
- Conditions
- Interventions
- First Posted Date
- 2016-09-21
- Last Posted Date
- 2020-05-22
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 80
- Registration Number
- NCT02909439
- Locations
- 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States
Drug Development Updates
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