Collagenase clostridium histolyticum
- Generic Name
- Collagenase clostridium histolyticum
- Brand Names
- Qwo, Santyl, Xiaflex
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9001-12-1
- Unique Ingredient Identifier
- 9X7O8V25IT
- Background
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers.
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- Indication
Collagenase clostridium histolyticum is indicated for the treatment of adults with Dupuytren's contracture with a palpable cord. Additionally, it is used to treat men with Peyronie's disease diagnosed with a penile curvature deformity of at least a 30-degree angle at the beginning of therapy in addition to palpable plaques. Collagenase ointment is used for t...
- Associated Conditions
- Dupuytren's Contracture of the Hand (Viking's Disease), Peyronie's Disease, Necrotic tissue
- Associated Therapies
- -
Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.
- First Posted Date
- 2013-12-09
- Last Posted Date
- 2015-07-16
- Lead Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
- Registration Number
- NCT02004626
- Locations
- 🇧🇷
Clínica Dr. Norton Sayeg Ltda, São Paulo, Brazil
A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma
- First Posted Date
- 2012-06-07
- Last Posted Date
- 2016-10-06
- Lead Sponsor
- Zachary Gerut
- Target Recruit Count
- 14
- Registration Number
- NCT01613313
- Locations
- 🇺🇸
Zachary E. Gerut, M.D., Hewlett, New York, United States
Collagenase Option for Reduction of Dupuytren's Contracture in Japan
- Conditions
- Interventions
- First Posted Date
- 2012-04-30
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Asahi Kasei Pharma Corporation
- Target Recruit Count
- 104
- Registration Number
- NCT01588353
Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers
- First Posted Date
- 2010-06-14
- Last Posted Date
- 2013-05-31
- Lead Sponsor
- Healthpoint
- Target Recruit Count
- 20
- Registration Number
- NCT01143727
- Locations
- 🇺🇸
Richard C. Galperin, DPM, Dallas, Texas, United States
A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers
- First Posted Date
- 2010-06-14
- Last Posted Date
- 2013-05-06
- Lead Sponsor
- Healthpoint
- Target Recruit Count
- 57
- Registration Number
- NCT01143714
- Locations
- 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
🇺🇸The Foot and Ankle Institute of Western Pennsylvania, Pittsburgh, Pennsylvania, United States
🇺🇸Boston Medical Center, Boston, Massachusetts, United States
Santyl vs. Sharp Debridement of Diabetic Foot Wounds
- Conditions
- Interventions
- First Posted Date
- 2010-01-26
- Last Posted Date
- 2012-11-21
- Lead Sponsor
- Healthpoint
- Target Recruit Count
- 48
- Registration Number
- NCT01056198
- Locations
- 🇺🇸
St. Elizabeth Regional Medical Center, Lincoln, Nebraska, United States
🇺🇸UNTHSC Fort Worth, Fort Worth, Texas, United States
🇺🇸Advanced Regional Center for Ankle and Foot Care, Altoona, Pennsylvania, United States
Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)
- First Posted Date
- 2005-12-02
- Last Posted Date
- 2019-10-03
- Lead Sponsor
- Stony Brook University
- Registration Number
- NCT00261196
- Locations
- 🇺🇸
Dept. Orthopaedics, SUNY@Stony Brook, Stony Brook, New York, United States
Collagenase in the Treatment of Cellulite
- Conditions
- First Posted Date
- 2005-12-02
- Last Posted Date
- 2012-12-12
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 20
- Registration Number
- NCT00261144
- Locations
- 🇺🇸
Dept. Orthopaedics, SUNY Stony Brook, Stony Brook, New York, United States
Collagenase in the Treatment of Zone II Flexor Tendon Adhesions in the Hand
- Conditions
- Interventions
- First Posted Date
- 2005-12-02
- Last Posted Date
- 2016-04-21
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 3
- Registration Number
- NCT00261209
- Locations
- 🇺🇸
Dept. Orthopaedics, SUNY@Stony Brook, Stony Brook, New York, United States
Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease
- Conditions
- First Posted Date
- 2001-04-11
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- State University of New York
- Target Recruit Count
- 72
- Registration Number
- NCT00014742
Drug Development Updates
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