利福喷丁 (Priftin)

概览

Rifapentine is an antibiotic agent used in the treatment of pulmonary tuberculosis.

作用机制

Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

适应症

For the treatment of pulmonary tuberculosis.

• Active Tuberculosis
• Late phase Tuberculosis