Tinlorafenib
- Generic Name
- Tinlorafenib
- Drug Type
- Small Molecule
- CAS Number
- 2573781-75-4
- Unique Ingredient Identifier
- JNJ5N2RH5W
- Background
Tinlorafenib (PF-07284890) is a potent, selective, highly brain-penetrant, small-molecule inhibitor of BRAF V600 mutations.
A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
Phase 1
Terminated
- Conditions
- Brain Neoplasms, PrimaryMalignant NeoplasmsMalignant MelanomaBrain NeoplasmsCarcinoma, Non-Small-Cell Lung
- Interventions
- First Posted Date
- 2020-09-10
- Last Posted Date
- 2024-05-22
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 66
- Registration Number
- NCT04543188
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
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