Cimetidine
- Generic Name
- Cimetidine
- Brand Names
- Good Sense Heartburn Relief, Tagamet
- Drug Type
- Small Molecule
- Chemical Formula
- C10H16N6S
- CAS Number
- 51481-61-9
- Unique Ingredient Identifier
- 80061L1WGD
- Background
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
- Indication
Cimetidine is indicated to reduce gastric acid secretion and to treat the following disease states: duodenal ulcers, non-malignant gastric ulcers, gastroesophageal reflux disease, and pathological hypersecretion associated with Zollinger-Ellison Syndrome, systemic mastocytosis, and multiple endocrine adenomas. It is indicated for prophylaxis of recurrent gastric or duodenal ulcers, as adjunctive therapy in the management of cystic fibrosis in children, and to treat NSAID induced lesions and gastrointestinal symptoms.
- Associated Conditions
- Cystic Fibrosis (CF), Gastric hypersecretion, Gastro-esophageal Reflux Disease (GERD), Gastrointestinal Symptoms, Heartburn, Active Duodenal ulcer, Benign gastric ulcers, Develop NSAID-induced gastric ulcers, Recurrent Ulcers, Duodenal and Gastric
Papillary Serous Carcinoma of the Endometrium
- Conditions
- Endometrial Cancer
- Interventions
- First Posted Date
- 2007-08-13
- Last Posted Date
- 2014-07-03
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT00515073
- Locations
- 🇺🇸
M. D. Anderson Cancer Center - Orlando, Orlando, Florida, United States
🇺🇸UT MD Anderson Cancer Center, Houston, Texas, United States
Performance of Cimetidine-corrected MDRD Equation in Renal Transplant Patients
- First Posted Date
- 2007-05-17
- Last Posted Date
- 2010-01-06
- Target Recruit Count
- 59
- Registration Number
- NCT00475059
- Locations
- 🇫🇷
Nephrology unit, CHU Saint-Etienne, Saint-Etienne, France
Biological Therapy in Treating Patients With Metastatic Cancer
- Conditions
- Kidney CancerMelanoma (Skin)Unspecified Adult Solid Tumor, Protocol Specific
- First Posted Date
- 2004-07-01
- Last Posted Date
- 2011-05-11
- Lead Sponsor
- Hoag Memorial Hospital Presbyterian
- Target Recruit Count
- 30
- Registration Number
- NCT00002733
- Locations
- 🇺🇸
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
- Conditions
- Upper Gastrointestinal Bleeding
- Interventions
- First Posted Date
- 2002-09-11
- Last Posted Date
- 2019-11-25
- Lead Sponsor
- Bausch Health Americas, Inc.
- Target Recruit Count
- 354
- Registration Number
- NCT00045799
- Locations
- 🇺🇸
Verdugo Hills Hospital, Burbank, California, United States
🇺🇸Wellstar Kennestone Hospital, Marietta, Georgia, United States
🇺🇸PAB Clinical Research, Brandon, Florida, United States
A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection
- Conditions
- HIV Infections
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Community Research Initiative of New England
- Registration Number
- NCT00002092
- Locations
- 🇺🇸
CRI of New England, Brookline, Massachusetts, United States
Drug Development Updates
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