Cisatracurium
- Generic Name
- Cisatracurium
- Brand Names
- Nimbex
- Drug Type
- Small Molecule
- Chemical Formula
- C53H72N2O12
- CAS Number
- 96946-41-7
- Unique Ingredient Identifier
- QX62KLI41N
- Background
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate. Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. Cisatracurium is an R-cis-R-cis isomer of atracurium and has approximately 3 times its neuromuscular blocking potency. Compared to atracurium, cisatracurium produces a lower degree of histamine release.
- Indication
Cisatracurium is indicated as an adjunct to general anesthesia to facilitate tracheal intubation in adults and pediatric patients 1 month to 12 years of age. Cisatracurium is also indicated to provide skeletal muscle relaxation during surgery in adults and pediatric patients 2 to 12 years of age as a bolus or infusion maintenance and for mechanical ventilation in the ICU in adults.
- Associated Conditions
- -
- Associated Therapies
- General Anesthesia, Skeletal muscle relaxation for mechanical ventilation, Smooth muscle relaxation prior to radiological procedures therapy
THe Comparison of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients
- Conditions
- Adrenal SuppressionHemodynamic Instability
- Interventions
- First Posted Date
- 2014-04-11
- Last Posted Date
- 2014-04-14
- Lead Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
- Target Recruit Count
- 90
- Registration Number
- NCT02111265
A Study of Residual Curarization Incidence in China
- Conditions
- Perioperative/Postoperative ComplicationsPORC (Postoperative Residual Curarization)
- Interventions
- First Posted Date
- 2012-09-21
- Last Posted Date
- 2013-05-24
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 6090
- Registration Number
- NCT01690338
- Locations
- 🇨🇳
Tongji Hospital, Tongji Medical College of HUST, Wuhan, Hubei, China
🇨🇳The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
🇨🇳Xiangya Hospital of Central South University, Changsha, Hunan, China
Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
- Conditions
- Postoperative Residual CurarizationResidual Neuromuscular Block
- Interventions
- First Posted Date
- 2012-07-27
- Last Posted Date
- 2014-03-11
- Lead Sponsor
- Azienda Ospedaliera di Padova
- Target Recruit Count
- 120
- Registration Number
- NCT01651572
- Locations
- 🇮🇹
Azienda Ospedaliera di Padova, Padova, Italy
Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
- First Posted Date
- 2012-04-09
- Last Posted Date
- 2014-09-01
- Lead Sponsor
- Assistance Publique Hopitaux De Marseille
- Target Recruit Count
- 40
- Registration Number
- NCT01573715
- Locations
- 🇫🇷
Assistance Publique Hopitaux de Marseille, Marseille, France
Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia
- First Posted Date
- 2011-01-11
- Last Posted Date
- 2011-01-11
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT01273831
- Locations
- 🇮🇷
Al-zahra university hospital, Isfahan, Iran, Islamic Republic of
Pediatric Elective Intubation With and Without Muscle Relaxation Utilizing the Shikani Optical Stylet
- Conditions
- Intubation,Endotracheal
- Interventions
- Drug: Normal salineDrug: Cisatracurium
- First Posted Date
- 2009-06-03
- Last Posted Date
- 2020-08-18
- Lead Sponsor
- Rady Children's Hospital, San Diego
- Target Recruit Count
- 34
- Registration Number
- NCT00912990
- Locations
- 🇺🇸
Rady Children's Hospital, San Diego, California, United States
Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
- Conditions
- ARDS
- Interventions
- First Posted Date
- 2006-03-07
- Last Posted Date
- 2008-10-10
- Lead Sponsor
- Assistance Publique Hopitaux De Marseille
- Target Recruit Count
- 340
- Registration Number
- NCT00299650
- Locations
- 🇫🇷
Réanimation chirurgicale, Nimes, France
🇫🇷Réanimation Polyvalente, Avignon, France
🇫🇷Hôpital de la Tronche - Réanimation médicale, Grenoble, France
Drug Development Updates
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