MedPath

Bryostatin 1

Generic Name
Bryostatin 1
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C47H68O17
CAS Number
83314-01-6
Unique Ingredient Identifier
37O2X55Y9E
Background

Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.

Associated Conditions
-
Associated Therapies
-

Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

Phase 1
Completed
Conditions
Accelerated Phase Chronic Myelogenous Leukemia
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Adult Acute Myeloid Leukemia With Del(5q)
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
Blastic Phase Chronic Myelogenous Leukemia
Chronic Myelomonocytic Leukemia
Chronic Phase Chronic Myelogenous Leukemia
Interventions
Drug: bryostatin 1
Biological: sargramostim
Other: laboratory biomarker analysis
Other: pharmacological study
First Posted Date
2003-01-27
Last Posted Date
2013-01-09
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
35
Registration Number
NCT00012376
Locations
🇺🇸

Johns Hopkins University, Baltimore, Maryland, United States

Bryostatin 1 and Cisplatin in Treating Patients With Metastatic or Unresectable Stomach Cancer

Phase 2
Completed
Conditions
Stage IV Gastric Cancer
Stage III Gastric Cancer
Interventions
Drug: bryostatin 1
Drug: cisplatin
Other: laboratory biomarker analysis
First Posted Date
2003-01-27
Last Posted Date
2014-10-01
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
12
Registration Number
NCT00006389
Locations
🇺🇸

University of Southern California, Los Angeles, California, United States

Paclitaxel and Bryostatin 1 in Treating Patients With Advanced Pancreatic Cancer

Phase 2
Completed
Conditions
Duct Cell Adenocarcinoma of the Pancreas
Stage IV Pancreatic Cancer
Acinar Cell Adenocarcinoma of the Pancreas
Recurrent Pancreatic Cancer
Stage III Pancreatic Cancer
Interventions
First Posted Date
2003-01-27
Last Posted Date
2021-06-11
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
19
Registration Number
NCT00031694
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

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