Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures

Phase 2

Withdrawn

Conditions: Pain, Acute

Interventions: Drug: Morphine
Drug: Ketamine

First Posted Date: 2019-08-19

Last Posted Date: 2022-04-27

Lead Sponsor: The University of Texas Health Science Center, Houston

Registration Number: NCT04061330

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Vital Signs-Integrated Patient-Assisted Intravenous Opioid Analgesia for Post Surgical Pain

Phase 2

Active, not recruiting

Conditions: Pain
Respiratory Depression

Interventions: Device: VPIA pump
Drug: Morphine

First Posted Date: 2019-07-08

Last Posted Date: 2024-10-09

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 40

Registration Number: NCT04011163

Locations: 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival

Phase 1

Not yet recruiting

Conditions: Cardiac Arrest

Interventions: Drug: Ketamine Injectable Solution
Drug: Saline 0.9%
Drug: Morphine

First Posted Date: 2019-07-05

Last Posted Date: 2021-06-11

Lead Sponsor: University Hospital, Akershus

Target Recruit Count: 240

Registration Number: NCT04009759

Erector Spinae Plane Block in Scoliotic Adolescents

Phase 2

Completed

Conditions: Scoliosis; Adolescence
Scoliosis Idiopathic
Erector Spinae Plane Block

Interventions: Procedure: Erector Spinae Plane Block
Drug: additional Fentanyl
Drug: Fentanyl
Drug: rescue Morphine
Drug: Morphine
Drug: pethidine
Drug: Ketorolac
Drug: Acetaminophen

First Posted Date: 2019-05-30

Last Posted Date: 2019-12-03

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 30

Registration Number: NCT03968146

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease

Phase 3

Terminated

Conditions: Sickle Cell Disease

Interventions: Other: Patient-Specific Protocol
Other: Weight-based Protocol
Drug: Morphine
Drug: Hydromorphone

First Posted Date: 2019-05-01

Last Posted Date: 2023-07-03

Lead Sponsor: Duke University

Target Recruit Count: 328

Registration Number: NCT03933397

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸
University of Maryland, Baltimore, Maryland, United States
🇺🇸
Henry Ford Health System, Detroit, Michigan, United States

and more 3 locations