Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: Morphine
Drug: Morphine plus Nalbuphine

First Posted Date: 2016-03-23

Last Posted Date: 2017-12-27

Lead Sponsor: Abdelrady S Ibrahim, MD

Target Recruit Count: 80

Registration Number: NCT02716129

Locations: 🇪🇬
Assiut university faculty of medicine, Assiut, Egypt

Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine
Drug: Dexamethasone
Drug: Paracetamol
Drug: Morphine
Drug: Lidocaine

First Posted Date: 2016-03-04

Last Posted Date: 2020-08-20

Lead Sponsor: Foisor Orthopedics Clinical Hospital

Target Recruit Count: 180

Registration Number: NCT02698995

Locations: 🇷🇴
Foisor Orthopedic Clinical Hospital, Bucharest, Romania

Regional Anaesthesia for Painful Injuries After Disasters

Phase 4

Withdrawn

Conditions: Fracture
Lower Limb Injuries

Interventions: Drug: Bupivacaine (femoral nerve block)
Drug: Morphine
Device: Ultrasound

First Posted Date: 2016-03-03

Last Posted Date: 2017-06-14

Lead Sponsor: Epicentre

Registration Number: NCT02698228

Delirium in Elderly Patients With Trauma of the Hip

Phase 4

Terminated

Conditions: Hip Fractures
Anesthesia

Interventions: Drug: Bupivacaine
Drug: Acetaminophen
Drug: Levobupivacaine
Drug: Diclofenac
Drug: Ropivacaine
Drug: Ibuprofen
Drug: Naproxen
Drug: Dipyrone
Drug: Fentanyl
Drug: Morphine

First Posted Date: 2016-02-23

Last Posted Date: 2023-08-04

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 239

Registration Number: NCT02689024

Locations: 🇳🇱
Meander Medical Center, Amersfoort, Netherlands
🇳🇱
VU Medical Center, Amsterdam, Netherlands
🇳🇱
Academic Medical Center, Amsterdam, Netherlands

and more 2 locations