The Transversus Abdominis Plane Block
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Total morphine consumption during 24 hours
研究概览
简要总结
The transversus abdominis plane block (TAP block) has effect to postoperative analgesia for cesarean section with spinal anesthesia but it was limited for cesarean section with general anesthesia. The hypothesis that this technique has effect to postoperative analgesia for cesarean section with general anesthesia and it could reduce 50% of total morphine consumption during 24 hours after surgery.
详细描述
This is a randomized, controlled, no-blind clinical trial. The investigators selected 60 cases, who were cesarean section under general anesthesia, age from18 years, and American Society Anesthesiologists (ASA) classification was from II-III. The cases of acute fetal impairment, local anesthesia contraindication, tolerance opioids, liver failure, renal failure, and spinal anesthesia failure were excluded. All cases were randomized assigned two groups: the TAP block group (T group) and controlled group (C group). Each group has 30 cases. The TAP block was performed under the ultrasound guidance with 0.25% of ropivacaine 20 ml each side. The both groups was treated postoperative analgesia with intravenous morphine to patients controlled analgesia (PCA). The primary outcome was total morphine consumption during 24 hours after surgery. The secondary outcomes were the time of required the first dose of morphine, pain score, the complications of TAP block, the side effects of morphine, and satisfaction score of participants. Data was described and analyzed with SPSS 25.0. The sample size was calculated with the hypothesis that TAP block could reduce 50% of dose morphine during 24 hours after surgery, 80% of power, 10% of loss, and 0.05 of alpha error.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
盲法说明
Participants were cesarean section with general anesthesia
入排标准
- 年龄范围
- 18 Years 至 50 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Cesarean section with general anesthesia.
- •The ASA classification was from II to III
排除标准
- •The acute fetal impairment.
- •The severe live or renal failure.
- •Tolerance opioids
研究组 & 干预措施
T group
The TAP block group was called T group. The participants were performed TAP block under guidance at the end of surgery.
干预措施: TAP block (Procedure)
T group
The TAP block group was called T group. The participants were performed TAP block under guidance at the end of surgery.
干预措施: Morphine (Drug)
T group
The TAP block group was called T group. The participants were performed TAP block under guidance at the end of surgery.
干预措施: Ropivacaine (Drug)
C group
The controlled group was called C group. The participants has not TAP block and were treated postoperative analgesia with intravenous morphine to patients controlled analgesia
干预措施: Morphine (Drug)
C group
The controlled group was called C group. The participants has not TAP block and were treated postoperative analgesia with intravenous morphine to patients controlled analgesia
干预措施: Ropivacaine (Drug)
结局指标
主要结局
Total morphine consumption during 24 hours
时间窗: 24 hours
Morphine was intravenous perfusion to participants during 24 hours with patients controlled analgesia (PCA).
次要结局
- The time required the first of dose of morphine (hours)(24 hours)
- Pain score: VAS(24 hours)
- The rate of complications of TAP block(24 hours)
- The rate of side effect of morphine(24 hours)
- The satisfaction of participants: Likert(24 hours)
