Overview
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was granted FDA approval in 1941.
Indication
Morphine is used for the management of chronic, moderate to severe pain. Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
Associated Conditions
- Chronic Pain
- Severe Pain
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/09/01 | Phase 4 | Completed | Universiti Kebangsaan Malaysia Medical Centre | ||
2023/08/24 | Phase 4 | Completed | National University of Malaysia | ||
2023/07/27 | Not Applicable | Completed | |||
2023/06/27 | Phase 4 | Recruiting | University Hospital Ostrava | ||
2023/06/22 | Phase 3 | Active, not recruiting | |||
2023/06/15 | Phase 4 | Recruiting | Pouya Azar | ||
2023/05/30 | Not Applicable | Recruiting | |||
2023/05/10 | Not Applicable | Completed | |||
2023/05/08 | Phase 4 | Not yet recruiting | Qianfoshan Hospital | ||
2023/04/06 | Phase 2 | Recruiting | Instituto Nacional de Cancer, Brazil |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Sun Pharmaceutical Industries, Inc. | 63304-453 | ORAL | 200 mg in 1 1 | 12/14/2023 | |
| Mayne Pharma Commercial LLC | 51862-188 | ORAL | 100 mg in 1 1 | 7/6/2023 | |
| Zydus Pharmaceuticals (USA) Inc. | 68382-907 | ORAL | 200 mg in 1 1 | 12/17/2021 | |
| Mayne Pharma Commercial LLC | 51862-187 | ORAL | 60 mg in 1 1 | 7/6/2023 | |
| Winder Laboratories LLC | 75826-129 | ORAL | 10 mg in 5 mL | 2/28/2022 | |
| RedPharm Drug, Inc. | 67296-1753 | ORAL | 15 mg in 1 1 | 1/21/2022 | |
| Purdue Pharma LP | 59011-260 | ORAL | 15 mg in 1 1 | 3/23/2017 | |
| SpecGx LLC | 0406-5118 | ORAL | 15 mg in 1 1 | 3/21/2024 | |
| Mayne Pharma Commercial LLC | 51862-615 | ORAL | 15 mg in 1 1 | 7/5/2023 | |
| Cantrell Drug Company | 52533-161 | INTRAVENOUS, INTRAMUSCULAR, INTRATHECAL, EPIDURAL | 2 mg in 1 mL | 5/1/2014 |
EMA Drug Approvals
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Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
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Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| M.O.S.-60 TAB 60MG | valeant canada lp / valeant canada s.e.c. | 00690244 | Tablet - Oral | 60 MG | 12/31/1986 |
| MS CONTIN SUPPOSITORIES - 100MG | purdue pharma | 02145952 | Suppository (Sustained-Release) - Rectal | 100 MG / SUP | 12/31/1995 |
| NTP-MORPHINE SR | teva canada limited | 02346389 | Tablet (Extended-Release) - Oral | 60 MG | N/A |
| MS CONTIN XL CAPSULES | purdue pharma | 02242828 | Capsule (Sustained-Release) - Oral | 60 MG / SRC | N/A |
| MS.IR | purdue pharma | 02014211 | Tablet (Immediate Release) - Oral | 10 MG | 12/31/1993 |
| MORPHINE SULFATE INJECTION, USP | fresenius kabi canada ltd | 02482703 | Solution - Subcutaneous
,
Intravenous
,
Intramuscular | 4 MG / 1 ML | N/A |
| STATEX | Endo Operations Ltd. | 00594652 | Tablet - Oral | 5 MG | 12/31/1985 |
| PMS-MORPHINE SULFATE SR 15 MG | 02245284 | Tablet (Extended-Release) - Oral | 15 MG | 2/20/2002 | |
| PMS-MORPHINE SULFATE | 02549816 | Tablet - Oral | 25 MG | N/A | |
| MORPHINE SULPHATE INJECTION,USP LIQ 1.1MG/ML | International Medication Systems Ltd. | 02010364 | Liquid - Intravenous
,
Refer (See Dosage Form) | 1.1 MG / ML | 12/31/1993 |
CIMA AEMPS Drug Approvals
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Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
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Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
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Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
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Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
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Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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