Voclosporin

Generic Name
Voclosporin
Brand Names
Lupkynis
Drug Type
Small Molecule
Chemical Formula
C63H111N11O12
CAS Number
515814-01-4
Unique Ingredient Identifier
2PN063X6B1
Background

Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE). LN is a significant cause of renal failure, morbidity, and death in patients with SLE. Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. Early and accurate interve...

Indication

联合免疫抑制疗法治疗成人活动性狼疮肾炎（LN）。

Associated Conditions
Lupus Nephritis
Associated Therapies
-
Clinical Trials
Related News

Examining Distinct Immunophenotypes to Validate and Enhance Rational Treatment in Systemic Lupus

First Posted Date
2022-04-01
Last Posted Date
2024-01-19
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
120
Registration Number
NCT05306873
Locations
🇺🇸

UCLA Medical Center: Division of Rheumatology, Los Angeles, California, United States

🇺🇸

Yale University School of Medicine: Rheumatology, Allergy & Immunology, New Haven, Connecticut, United States

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Emory University School of Medicine: Division of Rheumatology, Atlanta, Georgia, United States

and more 8 locations

Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin

Phase 1
Completed
Conditions
Drug-drug Interaction
Interventions
Drug: Simvastatin
Drug: Voclosporin
First Posted Date
2022-04-01
Last Posted Date
2022-04-20
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
24
Registration Number
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Locations
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Labcorp Clinical Research Unit, Dallas, Texas, United States

Voclosporin in Adolescents With Lupus Nephritis

First Posted Date
2022-03-21
Last Posted Date
2023-10-23
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
40
Registration Number
NCT05288855
Locations
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UNC-Chapel Hill, Chapel Hill, North Carolina, United States

Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients

First Posted Date
2021-01-08
Last Posted Date
2024-10-17
Lead Sponsor
Leiden University Medical Center
Target Recruit Count
20
Registration Number
NCT04701528
Locations
🇳🇱

Leiden University Medical Center, Leiden, Netherlands

Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis

Phase 2
Terminated
Conditions
Focal Segmental Glomerulosclerosis
Interventions
Drug: Voclosporin
First Posted Date
2018-07-26
Last Posted Date
2021-09-16
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
5
Registration Number
NCT03598036
Locations
🇩🇴

FSGS Investigative Center, Santo Domingo, Dominican Republic

🇺🇸

FSGS Investigative Site, Salt Lake City, Utah, United States

🇩🇴

FSGS Investigative Centre, Santiago De Los Caballeros, Dominican Republic

Aurinia Renal Assessments 2: Aurinia Renal Response in Lupus With Voclosporin

Phase 3
Completed
Conditions
Lupus Nephritis
Interventions
Drug: Placebo Oral Capsule
Drug: Voclosporin
First Posted Date
2018-07-24
Last Posted Date
2022-12-14
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
216
Registration Number
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Locations
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AURORA Investigative Center, Oklahoma City, Oklahoma, United States

Aurinia Renal Response in Active Lupus With Voclosporin

Phase 3
Completed
Conditions
Lupus Nephritis
Interventions
Drug: Voclosporin
Drug: Placebo Oral Capsule
First Posted Date
2017-01-16
Last Posted Date
2023-03-27
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
358
Registration Number
NCT03021499
Locations
🇻🇳

AURORA Investigative Center, Ho Chi Minh City, Vietnam

🇧🇾

AURORA Investigative Cener, Minsk, Belarus

🇺🇸

AURORA, Richmond, Virginia, United States

Voclosporin in Healthy Japanese Volunteers

Phase 1
Completed
Conditions
Volunteers
Interventions
Drug: Voclosporin
First Posted Date
2016-10-31
Last Posted Date
2018-01-17
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
40
Registration Number
NCT02949999
Locations
🇵🇭

MAD VCS Site, Dasmarinas City, Cavite, Philippines

Aurinia Early Urinary Protein Reduction Predicts Response

Phase 2
Completed
Conditions
Lupus Nephritis
Interventions
Drug: voclosporin
First Posted Date
2016-10-31
Last Posted Date
2021-03-19
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Target Recruit Count
10
Registration Number
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Locations
🇲🇾

AURION Site, Kuala Lumpur, Malaysia

Safety and Efficacy Study of Voclosporin and Tacrolimus in Transplantation

Phase 3
Withdrawn
Conditions
Renal Transplantation
Interventions
Drug: voclosporin
Drug: tacrolimus
First Posted Date
2012-04-27
Last Posted Date
2014-01-20
Lead Sponsor
Aurinia Pharmaceuticals Inc.
Registration Number
NCT01586845
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