Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Associated Therapies: -

Clinical Trials

Massage Therapy for Chronic Low Back Pain

Phase 2

Completed

Conditions: Low Back Pain

Interventions: Other: Massage
Drug: Ibuprofen

First Posted Date: 2013-10-31

Last Posted Date: 2014-09-09

Lead Sponsor: Chengdu University of Traditional Chinese Medicine

Target Recruit Count: 150

Registration Number: NCT01973010

Locations: 🇨🇳
Acupuncture and Tuina college of Chengdu University of TCM, Chengdu, Sichuan, China

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Phase 4

Completed

Conditions: Postoperative Pain
Analgesia

Interventions: Drug: Ibuprofen
Drug: Morphine
Drug: Gabapentin
Drug: Paracetamol

First Posted Date: 2013-10-21

Last Posted Date: 2013-10-21

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 180

Registration Number: NCT01966172

Locations: 🇩🇰
Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

Phase 4

Completed

Conditions: Pain

Interventions: Other: Placebo
Drug: Dexamethasone
Drug: Morphine
Drug: Zofran
Drug: Paracetamol
Drug: Ibuprofen

First Posted Date: 2013-10-01

Last Posted Date: 2015-10-27

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 160

Registration Number: NCT01953978

Locations: 🇩🇰
Glostrup University Hospital, Glostrup, Denmark

Percutaneous Pin Removal in Children - is Analgesia Necessary?

Not Applicable

Completed

Conditions: Elbow Fracture

Interventions: Drug: Acetaminophen
Drug: Ibuprofen
Other: Vitamin C

First Posted Date: 2013-09-17

Last Posted Date: 2013-09-17

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 240

Registration Number: NCT01944085

Locations: 🇸🇬
KK Women's & Children's Hospital, Singapore, Singapore

Effect IV Ibuprofen and Inflammatory Responses

Phase 4

Completed

Conditions: Gallbladder Disease

Interventions: Drug: ibuprofen
Other: sugar water/placebo

First Posted Date: 2013-09-10

Last Posted Date: 2016-12-21

Lead Sponsor: University of Medicine and Dentistry of New Jersey

Target Recruit Count: 60

Registration Number: NCT01938040

Locations: 🇺🇸
New York Methodist Hospital, Brooklyn, New York, United States
🇺🇸
New York University Hospital, New York, New York, United States
🇺🇸
MT. Sinai Medical Center, New York, New York, United States

and more 1 locations