Overview
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.
Indication
用于防治高血压、冠心病、心绞痛和充血性心力衰竭。
Associated Conditions
- Hypertension
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2017/03/20 | Early Phase 1 | Completed | |||
2014/06/20 | Phase 3 | Completed | |||
2014/05/13 | Not Applicable | UNKNOWN | |||
2013/07/10 | Phase 1 | Completed | |||
2013/02/06 | Phase 2 | Terminated | |||
2012/08/06 | Not Applicable | Completed | |||
2009/05/28 | Phase 2 | Completed | |||
2008/09/16 | Phase 2 | Completed | |||
2008/01/15 | Phase 1 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Epic Pharma, LLC | 42806-264 | ORAL | 5 mg in 1 1 | 3/15/2021 | |
| Carilion Materials Management | 68151-1333 | ORAL | 5 mg in 1 1 | 3/12/2012 | |
| Actavis Pharma, Inc. | 16252-539 | ORAL | 2.5 mg in 1 1 | 11/30/2023 | |
| Elite Laboratories, Inc. | 64850-910 | ORAL | 2.5 mg in 1 1 | 12/28/2022 | |
| Actavis Pharma, Inc. | 16252-540 | ORAL | 5 mg in 1 1 | 11/30/2023 | |
| Epic Pharma, LLC | 42806-263 | ORAL | 2.5 mg in 1 1 | 3/15/2021 | |
| AvKARE | 42291-062 | ORAL | 2.5 mg in 1 1 | 6/9/2023 | |
| Elite Laboratories, Inc. | 64850-911 | ORAL | 5 mg in 1 1 | 12/28/2022 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
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