Lidocaine

Generic Name: Lidocaine

Brand Names: Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₂₂N_₂O

CAS Number: 137-58-6

Unique Ingredient Identifier: 98PI200987

Background: Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication: Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions: Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal

Associated Therapies: Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Clinical Trials

To Compare lidocaine2%/Clonidine in Combination, With Bupivacaine 0.5 % Alone in Equal Volumes for Combined Sciatic-saphenous Nerve Block in Terms of Selectivity of Blockade

Phase 4

Completed

Conditions: Bimalleolar Fractures of the Ankle.
Saphenous Nerve Block.
Sciatic Nerve Block.
Post Operative Analgesia Duration.

Interventions: Drug: Lidocaine
Drug: Bupivacaine

First Posted Date: 2013-01-03

Last Posted Date: 2013-11-19

Lead Sponsor: Cork University Hospital

Target Recruit Count: 30

Registration Number: NCT01759524

Locations: 🇮🇪
Cork University Hospital, Cork, Ireland

Local Anesthetics for Pain Reduction Prior to IV Line Placement

Phase 4

Completed

Conditions: Pain
Local Anesthesia for Peripheral Intravenous Catheterization

Interventions: Drug: Buffered Lidocaine
Drug: Bacteriostatic Normal Saline
Drug: Lidocaine

First Posted Date: 2013-01-03

Last Posted Date: 2022-07-15

Lead Sponsor: Allina Health System

Target Recruit Count: 150

Registration Number: NCT01759459

Locations: 🇺🇸
United Hospital, part of Allina Health Services, Saint Paul, Minnesota, United States

Bupivacaine Versus Lidocaine Local Anesthesia

Phase 4

Completed

Conditions: Trigger Finger
Carpal Tunnel Syndrome

Interventions: Drug: Lidocaine
Drug: Bupivacaine

First Posted Date: 2012-12-18

Last Posted Date: 2015-12-14

Lead Sponsor: University of British Columbia

Target Recruit Count: 135

Registration Number: NCT01751347

Locations: 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada

The Effect of Topical Lidocaine on Pain Scores During Manual Vacuum Aspiration for Nonviable Pregnancies

Phase 3

Completed

Conditions: Nonviable Pregnancy

Interventions: Drug: Placebo gel
Drug: Lidocaine

First Posted Date: 2012-10-16

Last Posted Date: 2016-07-20

Lead Sponsor: Bridgeport Hospital

Target Recruit Count: 70

Registration Number: NCT01708330

Locations: 🇺🇸
Women and Infants Hospital Triage, Providence, Rhode Island, United States

Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies.

Phase 3

Completed

Conditions: Lumbago
Low Back Pain
Modic I Discopathy

Interventions: Drug: Hydrocortancyl.
Drug: Lidocaine

First Posted Date: 2012-09-26

Last Posted Date: 2020-02-05

Lead Sponsor: University Hospital, Montpellier

Target Recruit Count: 50

Registration Number: NCT01694134

Locations: 🇫🇷
Hospital University of Montpellier, Montpellier, France

Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy

Phase 2

Terminated

Conditions: Geographic Atrophy

Interventions: Drug: Lidocaine
Drug: Sirolimus

First Posted Date: 2012-08-30

Last Posted Date: 2015-12-10

Lead Sponsor: National Eye Institute (NEI)

Target Recruit Count: 52

Registration Number: NCT01675947

Locations: 🇺🇸
University of Florida HSC, Jacksonville, Florida, United States
🇺🇸
Vision Research Foundation, Grand Rapids, Michigan, United States
🇺🇸
Elman Retina Group, Baltimore, Maryland, United States

and more 10 locations