MedPath

Lorvotuzumab mertansine

Generic Name
Lorvotuzumab mertansine
Drug Type
Biotech
CAS Number
1008106-64-6
Unique Ingredient Identifier
0IVD6ASY0W
Background

Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.

A Study of IMGN901 for Patients With Advanced Solid Tumors and Extensive Stage Small Cell Lung Cancer

Phase 1
Terminated
Conditions
Small Cell Lung Cancer
Interventions
First Posted Date
2010-11-09
Last Posted Date
2018-01-18
Lead Sponsor
ImmunoGen, Inc.
Target Recruit Count
181
Registration Number
NCT01237678
Locations
🇺🇸

Johns Hopkins University, Baltimore, Maryland, United States

🇪🇸

Hospital Universitario Virgen del Rocio, Sevilla, Spain

🇬🇧

Royal Marsden, London, London, United Kingdom

and more 44 locations

IMGN901 in Combination With Lenalidomide and Dexamethasone

Phase 1
Completed
Conditions
Multiple Myeloma
First Posted Date
2009-10-08
Last Posted Date
2014-11-21
Lead Sponsor
ImmunoGen, Inc.
Target Recruit Count
50
Registration Number
NCT00991562
Locations
🇺🇸

Comprehensive Cancer Center of the Desert, Palm Springs, California, United States

🇺🇸

Weill Medical College, New York, New York, United States

🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

and more 6 locations

BB-10901 in Treating Patients With Relapsed or Refractory Solid Tumors

Phase 1
Completed
Conditions
Ovarian Cancer
Merkel Cell Carcinoma
SCLC
First Posted Date
2006-06-29
Last Posted Date
2015-03-26
Lead Sponsor
ImmunoGen, Inc.
Target Recruit Count
97
Registration Number
NCT00346385
Locations
🇺🇸

University of California San Francisco, San Francisco, California, United States

🇺🇸

Oklahoma University, Oklahoma City, Oklahoma, United States

🇺🇸

M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States

and more 6 locations

BB-10901 in Treating Patients With Relapsed and/or Refractory Multiple Myeloma

Phase 1
Completed
Conditions
Multiple Myeloma
First Posted Date
2006-06-29
Last Posted Date
2013-04-23
Lead Sponsor
ImmunoGen, Inc.
Target Recruit Count
37
Registration Number
NCT00346255
Locations
🇦🇷

Juan Domingo Peron 1500 - (B1629AHJ) Pilar, Buenos Aires, Argentina

🇺🇸

St. Vincent's Comprehensive Cancer Center - Manhattan, New York, New York, United States

🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

and more 5 locations

Safety Study Using Weekly Infusions of BB-10901 in Patients With Small Cell Lung Cancer

Phase 1
Completed
Conditions
Small Cell Lung Cancer
Interventions
First Posted Date
2003-07-24
Last Posted Date
2012-07-18
Lead Sponsor
ImmunoGen, Inc.
Target Recruit Count
64
Registration Number
NCT00065429
Locations
🇺🇸

Greater Dayton Cancer Center, Kettering, Ohio, United States

🇺🇸

The Ohio State University, Colombus, Ohio, United States

🇺🇸

Baystate Medical Center, Springfield, Massachusetts, United States

and more 8 locations
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