Phenytoin
生产企业：Parke davis div warner lambert co, Actavis mid atlantic llc，另有 25 家
Phenytoin is an anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Phenytoin is an anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Although phenytoin first appeared in the literature in 1946, it has taken decades for the mechanism of action to be more specifically elucidated. Although several scientists were convinced that phenytoin altered sodium permeability, it wasn’t until the 1980’s that this phenomenon was linked to voltage-gated sodium channels. Phenytoin is often described as a non-specific sodium channel blocker and targets almost all voltage-gated sodium channel subtypes. More specifically, phenytoin prevents seizures by inhibiting the positive feedback loop that results in neuronal propagation of high frequency action potentials.
Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. Injectable phenytoin and Fosphenytoin, which is the phosphate ester prodrug formulation of phenytoin, are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurring during neurosurgery.
共 11 项相关疾病
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
