Paromomycin
- Generic Name
- Paromomycin
- Brand Names
- Humatin
- Drug Type
- Small Molecule
- Chemical Formula
- C23H45N5O14
- CAS Number
- 7542-37-2
- Unique Ingredient Identifier
- 61JJC8N5ZK
- Background
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
- Indication
For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
- Associated Conditions
- Dientamoeba fragilis infection, Hepatic coma, Acute Intestinal amebiasis, Chronic Intestinal amebiasis
Paromomycin or Metronidazole for Symptomatic Dientamoeba Fragilis in Adults
- First Posted Date
- 2025-04-02
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT06907498
- Locations
- 🇮🇱
Sheba medical center, Ramat Gan, Israel
LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study
- Conditions
- Primary Visceral Leishmaniasis
- Interventions
- First Posted Date
- 2023-07-24
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Drugs for Neglected Diseases
- Target Recruit Count
- 52
- Registration Number
- NCT05957978
- Locations
- 🇪🇹
University of Gondar, Gondar, Ethiopia
Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis
- Conditions
- Cutaneous Leishmaniasis, American
- Interventions
- First Posted Date
- 2019-02-04
- Last Posted Date
- 2021-02-02
- Lead Sponsor
- Fundacion Nacional de Dermatologia
- Target Recruit Count
- 120
- Registration Number
- NCT03829917
- Locations
- 🇧🇴
Hopital, Dermatologico, Jorochito, SC, Bolivia
Oral Antibiotic Prophylaxis in Colorectal Surgery
- Conditions
- Surgical Site InfectionAnastomotic Leak
- Interventions
- First Posted Date
- 2018-11-30
- Last Posted Date
- 2020-01-07
- Lead Sponsor
- University of Leipzig
- Target Recruit Count
- 100
- Registration Number
- NCT03759886
- Locations
- 🇩🇪
Universitätsklinikum Leipzig - AöR, Leipzig, Sachsen, Germany
Short Course Regimens for Treatment of PKDL (Sudan)
- Conditions
- PKDL - Post-Kala-Azar Dermal Leishmanioid
- Interventions
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2020-01-18
- Lead Sponsor
- Drugs for Neglected Diseases
- Target Recruit Count
- 110
- Registration Number
- NCT03399955
- Locations
- 🇸🇩
Prof. Elhassan Centre for tropical Medicine, Doka, Gedaref, Sudan
Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa
- Conditions
- Visceral Leishmaniasis
- Interventions
- First Posted Date
- 2017-04-26
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- Drugs for Neglected Diseases
- Target Recruit Count
- 439
- Registration Number
- NCT03129646
- Locations
- 🇪🇹
Abdurafi MSF Health Center, Ābderafī, Amhara, Ethiopia
🇸🇩El Hassan Centre for Tropical Medicine, Doka, Gedaref, Sudan
🇰🇪Kacheliba Hospital, Kapenguria, West Pokot, Kenya
Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
- Conditions
- Leishmaniasis, CutaneousLeishmania Braziliensis ComplexLeishmaniasis, AmericanLeishmaniasis; American, Cutaneous
- Interventions
- First Posted Date
- 2017-03-30
- Last Posted Date
- 2021-02-02
- Lead Sponsor
- Fundacion Nacional de Dermatologia
- Target Recruit Count
- 80
- Registration Number
- NCT03096457
- Locations
- 🇧🇴
Hospital Dermatologico de Jorochito, Jorochito, SC, Bolivia
🇧🇴Hospital Local Palos Blancos, Palos Blancos, La Paz, Bolivia
Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama
- First Posted Date
- 2013-02-13
- Last Posted Date
- 2018-02-14
- Lead Sponsor
- U.S. Army Medical Research and Development Command
- Target Recruit Count
- 399
- Registration Number
- NCT01790659
- Locations
- 🇵🇦
Instituto Conmemorativo Gorgas de Estudios de la Salud,, Panama City, Panama
The Use of a Non-absorbable Marker for the Evaluation of the Gastrointestinal Transit
- Conditions
- Concentration-Time Profiles in Stomach & Intestine.
- Interventions
- First Posted Date
- 2013-01-31
- Last Posted Date
- 2014-01-29
- Lead Sponsor
- KU Leuven
- Target Recruit Count
- 10
- Registration Number
- NCT01780909
- Locations
- 🇧🇪
Gasthuisberg, Leuven, BE, Belgium
Paromomycin for Individuals With Uncomplicated Cutaneous Leishmaniasis
- Conditions
- Leishmaniasis, Cutaneous
- First Posted Date
- 2012-07-17
- Last Posted Date
- 2020-05-15
- Lead Sponsor
- U.S. Army Medical Research and Development Command
- Registration Number
- NCT01641796
- Locations
- 🇺🇸
Military Treatment Facilities, Multiple Locations, Maryland, United States
🇺🇸Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Drug Development Updates
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