Fluvastatin
- Generic Name
- Fluvastatin
- Brand Names
- Lescol
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26FNO4
- CAS Number
- 93957-54-1
- Unique Ingredient Identifier
- 4L066368AS
- Background
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prev...
- Indication
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary ...
- Associated Conditions
- Atherosclerosis, Heterozygous Familial Hypercholesterolemia (HeFH), Mixed Dyslipidemias, Primary Hypercholesterolemia, Revascularization procedures
- Associated Therapies
- -
A Pilot Trial to Determine the Safety and Efficacy of Fluvastatin in Previous Partial Responders to Pegylated Interferon and Ribivirin in Patients With Genotype 1 Hepatitis C
- Conditions
- Interventions
- First Posted Date
- 2008-12-25
- Last Posted Date
- 2013-07-01
- Lead Sponsor
- University of Chicago
- Registration Number
- NCT00814606
Fluvastatin 80 mg Ret. vs Combination With Ezetimibe 10 mg in Patients With High Cardiovascular Risk
- Conditions
- Interventions
- First Posted Date
- 2008-12-25
- Last Posted Date
- 2008-12-25
- Lead Sponsor
- Medical University of Graz
- Target Recruit Count
- 90
- Registration Number
- NCT00814723
- Locations
- 🇦🇹
Depart. of Internal Medicine, Medical University of Graz, Graz, Austria
Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients
- First Posted Date
- 2008-05-07
- Last Posted Date
- 2018-05-01
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 41
- Registration Number
- NCT00674297
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
🇺🇸Division of Rheumatology, University of Texas Medical Branch, Galveston, Texas, United States
Evaluation of the Effect of Fluvastatin 40 mg (b.i.d.) in the Prevention of the Development of Vasculopathy of the Graft in de Novo Renal Transplant Patients Transplant
- First Posted Date
- 2007-11-30
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 84
- Registration Number
- NCT00565474
- Locations
- 🇪🇸
Novartis Investigative Site, Barcelona, Spain
Yokohama Assessment of Fluvastatin, Pravastatin, Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Yokohama-ACS)
- Conditions
- Interventions
- First Posted Date
- 2007-10-26
- Last Posted Date
- 2010-02-17
- Lead Sponsor
- Yokohama City University Medical Center
- Target Recruit Count
- 200
- Registration Number
- NCT00549926
- Locations
- 🇯🇵
Yokohama City University Medical Center, Yokohama, Japan
Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass
- Conditions
- Interventions
- First Posted Date
- 2007-06-21
- Last Posted Date
- 2011-02-18
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 793
- Registration Number
- NCT00489424
- Locations
- 🇺🇸
Refer to the E-portal link for ZOL446HUS136, Http://www.osteoporosisclinicalresearch.com, New Jersey, United States
Fluvastatin, Rosuvastatin Added to Pegylated Interferon and Ribavirin
- First Posted Date
- 2007-06-18
- Last Posted Date
- 2012-08-21
- Lead Sponsor
- Bader, Ted, M.D.
- Target Recruit Count
- 40
- Registration Number
- NCT00487318
- Locations
- 🇺🇸
Veterans Administration Medical Center, Oklahoma City, Oklahoma, United States
Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation
- Conditions
- First Posted Date
- 2007-04-25
- Last Posted Date
- 2007-04-25
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 100
- Registration Number
- NCT00465322
- Locations
- 🇨🇭
Cardiology University Hospital, Bern, Switzerland
Fluvastatin Versus Hepatitis C Virus
- Conditions
- First Posted Date
- 2007-03-01
- Last Posted Date
- 2012-07-27
- Lead Sponsor
- Bader, Ted, M.D.
- Target Recruit Count
- 32
- Registration Number
- NCT00441493
- Locations
- 🇺🇸
VA Medical Center, Oklahoma City, Oklahoma, United States
Fluvastatin After Heart Transplantation
- First Posted Date
- 2007-01-11
- Last Posted Date
- 2009-04-29
- Lead Sponsor
- University of Bologna
- Target Recruit Count
- 56
- Registration Number
- NCT00421005
- Locations
- 🇮🇹
Policlinico S.Orsola-Malpighi, Bologna, Italy
Drug Development Updates
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