Hydrochlorothiazide

Generic Name: Hydrochlorothiazide

Brand Names: Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac

Drug Type: Small Molecule

Chemical Formula: C_₇H_₈ClN_₃O_₄S_₂

CAS Number: 58-93-5

Unique Ingredient Identifier: 0J48LPH2TH

Background: Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers.

Hydrochlorothiazide was granted FDA approval on 12 February 1959.

Indication: Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.

Associated Conditions: Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke

Clinical Trials

Use of Nanotechnology Structured Water for the Prevention of Recurrent Stone Formation

Not Applicable

Completed

Conditions: Renal Stones
Idiopathic Hypercalciuria

Interventions: Dietary Supplement: structured nano-water
Drug: Hydrochlorothiazide (HCTZ)
Other: ordinary bottled drinking water

First Posted Date: 2024-11-08

Last Posted Date: 2024-11-08

Lead Sponsor: ALI KAMAL M. SAMI

Target Recruit Count: 325

Registration Number: NCT06681116

Locations: 🇮🇶
College of Medicine, University of Suliamani, Sulaymaniyah, Kurdistan Region, Iraq

Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention

Phase 2

Recruiting

Conditions: Kidney Stone

Interventions: Drug: Indapamide 2.5 MG
Drug: Hydrochlorothiazide 50Mg
Drug: Chlorthalidone 25mg

First Posted Date: 2023-11-01

Last Posted Date: 2025-02-19

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 99

Registration Number: NCT06111885

Locations: 🇨🇭
Inselspital, Department of Nephrology and Hypertension, Bern, Switzerland

Multi-Omics to Predict the Blood Pressure Response to Antihypertensives

Phase 4

Recruiting

Conditions: Primary Hypertension

Interventions: Drug: Amlodipine
Drug: Olmesartan
Drug: Hydrochlorothiazide
Drug: Amlodipine/Olmesartan

First Posted Date: 2023-06-23

Last Posted Date: 2024-06-10

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 96

Registration Number: NCT05917275

Locations: 🇳🇱
Radboudumc, Nijmegen, Netherlands

Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients

Phase 4

Not yet recruiting

Conditions: Urolithiasis
Hyperoxaluria

Interventions: Drug: Dapagliflozin
Drug: Hydrochlorothiazide

First Posted Date: 2022-07-05

Last Posted Date: 2023-10-23

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 32

Registration Number: NCT05443932

Locations: 🇦🇹
Medical University of Vienna, Vienna, Austria

HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life

Phase 3

Not yet recruiting

Conditions: ADPKD

Interventions: Drug: Hydrochlorothiazide 25 mg
Drug: Placebo

First Posted Date: 2022-05-13

Last Posted Date: 2023-09-29

Lead Sponsor: University Medical Center Groningen

Target Recruit Count: 300

Registration Number: NCT05373264

Locations: 🇩🇪
Charité University Hospital, Berlin, Germany
🇬🇧
Addenbrooke's Hospital, Cambridge, United Kingdom
🇧🇪
Cliniques Universitaires Saint-Luc, Brussel, Belgium

and more 10 locations