Hydrochlorothiazide
- Generic Name
- Hydrochlorothiazide
- Brand Names
- Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8ClN3O4S2
- CAS Number
- 58-93-5
- Unique Ingredient Identifier
- 0J48LPH2TH
- Background
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II rec...
- Indication
Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.
- Associated Conditions
- Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke
- Associated Therapies
- -
Multi-Omics to Predict the Blood Pressure Response to Antihypertensives
- Conditions
- Interventions
- First Posted Date
- 2023-06-23
- Last Posted Date
- 2024-06-10
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 96
- Registration Number
- NCT05917275
- Locations
- 🇳🇱
Radboudumc, Nijmegen, Netherlands
Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients
- Conditions
- Interventions
- First Posted Date
- 2022-07-05
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 32
- Registration Number
- NCT05443932
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide
- Conditions
- Interventions
- First Posted Date
- 2021-11-18
- Last Posted Date
- 2023-07-18
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 163720
- Registration Number
- NCT05125224
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)
- First Posted Date
- 2020-12-04
- Last Posted Date
- 2021-11-19
- Lead Sponsor
- Universität des Saarlandes
- Target Recruit Count
- 30
- Registration Number
- NCT04654312
- Locations
- 🇩🇪
Saarland University Hospital, Homburg, Saarland, Germany
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
- Conditions
- Interventions
- First Posted Date
- 2020-06-09
- Last Posted Date
- 2024-04-19
- Lead Sponsor
- University of Iowa
- Target Recruit Count
- 78
- Registration Number
- NCT04423627
- Locations
- 🇺🇸
Amy Stroud, Iowa City, Iowa, United States
🇺🇸University of Iowa, Iowa City, Iowa, United States
Hydrochlorothiazide and Risk of Skin Cancer
- Conditions
- Interventions
- First Posted Date
- 2020-04-06
- Last Posted Date
- 2023-06-29
- Target Recruit Count
- 2953748
- Registration Number
- NCT04334824
- Locations
- 🇨🇦
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada
Generation of Biological Samples Positive to Hydrochlorothiazide for Anti-doping Control
- First Posted Date
- 2019-12-13
- Last Posted Date
- 2019-12-13
- Lead Sponsor
- Parc de Salut Mar
- Target Recruit Count
- 3
- Registration Number
- NCT04197622
- Locations
- 🇪🇸
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria
- Conditions
- Interventions
- First Posted Date
- 2019-05-15
- Last Posted Date
- 2019-05-15
- Lead Sponsor
- Hospital Infantil de Mexico Federico Gomez
- Target Recruit Count
- 90
- Registration Number
- NCT03951558
- Locations
- 🇲🇽
Children's Hospital of Mexico, Federico Gómez, México, México City, Mexico
Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.
- Conditions
- Interventions
- First Posted Date
- 2019-04-19
- Last Posted Date
- 2019-04-22
- Lead Sponsor
- Anna Posadzy-Małaczyńska
- Target Recruit Count
- 180
- Registration Number
- NCT03921736
Protocol of Diuretics Use in Congestive Therapy in Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2019-03-27
- Last Posted Date
- 2021-04-15
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Target Recruit Count
- 300
- Registration Number
- NCT03892148
- Locations
- 🇫🇷
Ch Annecy, Annecy, France
🇫🇷CH PUY, Le Puy-en-Velay, France
🇫🇷CHU de GRENOBLE, Grenoble, France
Drug Development Updates
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