Hydrochlorothiazide
- Generic Name
- Hydrochlorothiazide
- Brand Names
- Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8ClN3O4S2
- CAS Number
- 58-93-5
- Unique Ingredient Identifier
- 0J48LPH2TH
- Background
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers.
Hydrochlorothiazide was granted FDA approval on 12 February 1959.
- Indication
Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.
- Associated Conditions
- Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke
Bioequivalence Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochloride Tablets Under Fasting Conditions.
- Conditions
- Healthy Subjects
- Interventions
- First Posted Date
- 2016-11-11
- Last Posted Date
- 2016-11-11
- Lead Sponsor
- Torrent Pharmaceuticals Limited
- Target Recruit Count
- 34
- Registration Number
- NCT02962336
DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease
- Interventions
- First Posted Date
- 2016-08-23
- Last Posted Date
- 2018-04-20
- Lead Sponsor
- Erasmus Medical Center
- Target Recruit Count
- 28
- Registration Number
- NCT02875886
- Locations
- 🇳🇱
ErasmusMC, Rotterdam, Netherlands
N-of-1 Trials for Blood Pressure Medications in Adults
- Conditions
- High Blood PressureHypertension
- Interventions
- First Posted Date
- 2016-04-20
- Last Posted Date
- 2019-03-26
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 10
- Registration Number
- NCT02744456
- Locations
- 🇺🇸
Columbia University Medical Center, New York, New York, United States
Clinical Trial to Compare the Pharmacokinetics of TAH Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers
- Conditions
- Healthy
- Interventions
- Drug: TAH Tablet (Telmisartan/Amlodipine besylate/Hydrochlorothiazide)Drug: TWYNSTA(Telmisartan+Amlodipine besylate)
- First Posted Date
- 2016-04-15
- Last Posted Date
- 2017-01-26
- Lead Sponsor
- IlDong Pharmaceutical Co Ltd
- Target Recruit Count
- 40
- Registration Number
- NCT02739672
- Locations
- 🇰🇷
Chonbuk National University Hospital, Chonbuk, Korea, Republic of
Efficacy and Safety of TAH Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients
- Conditions
- Essential Hypertension
- Interventions
- Drug: Telmisartan/AmlodipineDrug: Telmisartan/Amlodipine+Hydrochlorothiazide
- First Posted Date
- 2016-04-14
- Last Posted Date
- 2016-11-25
- Lead Sponsor
- IlDong Pharmaceutical Co Ltd
- Target Recruit Count
- 300
- Registration Number
- NCT02738632
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium
- Conditions
- Kidney Stones
- Interventions
- First Posted Date
- 2016-03-17
- Last Posted Date
- 2023-04-27
- Lead Sponsor
- VA New York Harbor Healthcare System
- Target Recruit Count
- 10
- Registration Number
- NCT02711670
- Locations
- 🇺🇸
VA New York Harbor Healthcare System, New York, New York, United States
Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
- First Posted Date
- 2016-03-16
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 41
- Registration Number
- NCT02710071
Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic
- Conditions
- Obstructive Sleep Apnea
- Interventions
- First Posted Date
- 2016-03-04
- Last Posted Date
- 2020-12-04
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 41
- Registration Number
- NCT02699125
Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension
- Conditions
- Chronic Kidney Disease
- Interventions
- First Posted Date
- 2016-01-05
- Last Posted Date
- 2016-01-05
- Lead Sponsor
- Shanghai Changzheng Hospital
- Target Recruit Count
- 508
- Registration Number
- NCT02646397
- Locations
- 🇨🇳
Department of Nephrology, Shanghai Changzheng Hospital, Shanghai, Shanghai, China
Efficacy and Safety of Fimasartan Alone or Combined With HCTZ in Mexican Patients With Essential Hypertension
- Conditions
- Hypertension, Essential
- Interventions
- First Posted Date
- 2015-06-09
- Last Posted Date
- 2015-06-09
- Lead Sponsor
- Stendhal Americas, S.A.
- Target Recruit Count
- 272
- Registration Number
- NCT02466490
- Locations
- 🇲🇽
Centro Médico Exel, Tijuana, Baja California, Mexico
🇲🇽Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
🇲🇽Unidad de Investigación Clínica Cardiometabólica de Occidente, Guadalajara, Jalisco, Mexico
Drug Development Updates
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