Amiloride

Generic Name
Amiloride
Brand Names
Midamor
Drug Type
Small Molecule
Chemical Formula
C6H8ClN7O
CAS Number
2609-46-3
Unique Ingredient Identifier
7DZO8EB0Z3
Background

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with ...

Indication

For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.

Associated Conditions
Ascites, Calcium Nephrolithiasis, Congestive Heart Failure (CHF), Hypertension, Hypokalemia, Metabolic Alkalosis, Polyuria
Associated Therapies
-

Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant

First Posted Date
2024-05-16
Last Posted Date
2024-05-16
Lead Sponsor
Ospedale San Raffaele
Target Recruit Count
40
Registration Number
NCT06416735
Locations
🇮🇹

San Raffaele Hospital, Milan, Lombardia, Italy

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

First Posted Date
2023-03-03
Last Posted Date
2024-06-04
Lead Sponsor
Yale University
Target Recruit Count
50
Registration Number
NCT05753059
Locations
🇺🇸

Yale University, New Haven, Connecticut, United States

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

Active, not recruiting
Conditions
Interventions
First Posted Date
2021-11-18
Last Posted Date
2023-07-18
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
146670
Registration Number
NCT05125237
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Amiloride in Nephrotic Syndrome

First Posted Date
2021-10-15
Last Posted Date
2023-07-05
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
20
Registration Number
NCT05079789
Locations
🇩🇪

University Hospital Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Phase 4
Completed
Conditions
Interventions
First Posted Date
2020-04-02
Last Posted Date
2024-08-26
Lead Sponsor
Yonsei University
Target Recruit Count
118
Registration Number
NCT04331691
Locations
🇰🇷

Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea, Republic of

Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers

Early Phase 1
Completed
Conditions
Interventions
First Posted Date
2019-11-29
Last Posted Date
2023-03-08
Lead Sponsor
University of Utah
Target Recruit Count
15
Registration Number
NCT04181008
Locations
🇺🇸

University of Utah, Salt Lake City, Utah, United States

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura

Phase 2
Recruiting
Conditions
Interventions
First Posted Date
2019-08-21
Last Posted Date
2024-07-10
Lead Sponsor
Centre Hospitalier Universitaire de Nice
Target Recruit Count
40
Registration Number
NCT04063540
Locations
🇫🇷

Hôpital Pierre Wertheimer, Bron, France

🇫🇷

CHU Gabriel Montpied, Clermont-Ferrand, France

🇫🇷

AP-HM, Marly, France

and more 2 locations

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein

First Posted Date
2017-05-31
Last Posted Date
2020-09-18
Lead Sponsor
Guangdong Provincial People's Hospital
Target Recruit Count
40
Registration Number
NCT03170336
Locations
🇨🇳

Nephrology Dept,Guangdong General Hospital, Guangzhou, Guangdong, China

DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease

First Posted Date
2016-08-23
Last Posted Date
2018-04-20
Lead Sponsor
Erasmus Medical Center
Target Recruit Count
28
Registration Number
NCT02875886
Locations
🇳🇱

ErasmusMC, Rotterdam, Netherlands

Comparison of Optimal Hypertension Regimens

First Posted Date
2016-07-28
Last Posted Date
2021-07-28
Lead Sponsor
Cambridge University Hospitals NHS Foundation Trust
Target Recruit Count
1320
Registration Number
NCT02847338
Locations
🇬🇧

Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

🇬🇧

University Hospital Llandough, Cardiff, United Kingdom

🇬🇧

Queen Elizabeth Hospital, Birmingham, United Kingdom

and more 11 locations
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