Amiloride
- Generic Name
- Amiloride
- Brand Names
- Midamor
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8ClN7O
- CAS Number
- 2609-46-3
- Unique Ingredient Identifier
- 7DZO8EB0Z3
- Background
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
- Indication
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.
- Associated Conditions
- Ascites, Calcium Nephrolithiasis, Congestive Heart Failure (CHF), Hypertension, Hypokalemia, Metabolic Alkalosis, Polyuria
Double Blind Crossover Comparison of Diuretics in the Young
- Conditions
- Low-Renin Hypertension
- First Posted Date
- 2007-02-01
- Last Posted Date
- 2007-02-01
- Lead Sponsor
- University of Cambridge
- Target Recruit Count
- 30
- Registration Number
- NCT00429897
- Locations
- 🇬🇧
University of Cambridge - Addenbrookes Hospital, Cambridge, United Kingdom
Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril
- Conditions
- Hypertension
- First Posted Date
- 2006-11-01
- Last Posted Date
- 2006-11-01
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Registration Number
- NCT00394394
- Locations
- 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
- Conditions
- Cystic Fibrosis
- First Posted Date
- 2006-01-10
- Last Posted Date
- 2006-01-10
- Lead Sponsor
- University of North Carolina
- Target Recruit Count
- 24
- Registration Number
- NCT00274391
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States
Extracellular Fluid in Resistant Hypertension
- Conditions
- Hypertension
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2015-06-09
- Lead Sponsor
- St George's, University of London
- Target Recruit Count
- 32
- Registration Number
- NCT00141596
- Locations
- 🇬🇧
Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL, London, United Kingdom
Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis
- Conditions
- Cystic Fibrosis
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- FDA Office of Orphan Products Development
- Registration Number
- NCT00004705
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.