Amiloride
- Generic Name
- Amiloride
- Brand Names
- Midamor
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8ClN7O
- CAS Number
- 2609-46-3
- Unique Ingredient Identifier
- 7DZO8EB0Z3
- Background
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with ...
- Indication
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.
- Associated Conditions
- Ascites, Calcium Nephrolithiasis, Congestive Heart Failure (CHF), Hypertension, Hypokalemia, Metabolic Alkalosis, Polyuria
- Associated Therapies
- -
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
Phase 2
Completed
- Conditions
- First Posted Date
- 2006-01-10
- Last Posted Date
- 2006-01-10
- Lead Sponsor
- University of North Carolina
- Target Recruit Count
- 24
- Registration Number
- NCT00274391
- Locations
- 🇺🇸
University of North Carolina, Chapel Hill, North Carolina, United States
Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis
Not Applicable
Completed
- Conditions
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- FDA Office of Orphan Products Development
- Registration Number
- NCT00004705
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