Amiloride
- Generic Name
- Amiloride
- Brand Names
- Midamor
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8ClN7O
- CAS Number
- 2609-46-3
- Unique Ingredient Identifier
- 7DZO8EB0Z3
- Background
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with ...
- Indication
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.
- Associated Conditions
- Ascites, Calcium Nephrolithiasis, Congestive Heart Failure (CHF), Hypertension, Hypokalemia, Metabolic Alkalosis, Polyuria
- Associated Therapies
- -
Amiloride Hydrochloride as an Effective Treatment for ADHD
- First Posted Date
- 2012-11-27
- Last Posted Date
- 2018-07-20
- Target Recruit Count
- 3
- Registration Number
- NCT01733680
- Locations
- 🇺🇸
SUNY Upstate Medical University, Syracuse, New York, United States
The Effect of Amiloride and Spironolactone in Patients With Hypertension
- First Posted Date
- 2011-07-06
- Last Posted Date
- 2012-03-28
- Lead Sponsor
- Erling Bjerregaard Pedersen
- Target Recruit Count
- 23
- Registration Number
- NCT01388088
- Locations
- 🇩🇰
Department of Medical Research, Holstebro, Denmark
Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
- First Posted Date
- 2011-03-04
- Last Posted Date
- 2012-10-23
- Lead Sponsor
- Augusta University
- Target Recruit Count
- 32
- Registration Number
- NCT01308983
- Locations
- 🇺🇸
Georgia Prevention Institute, Augusta, Georgia, United States
Microcirculation & ASICs
- Conditions
- First Posted Date
- 2010-11-23
- Last Posted Date
- 2019-05-28
- Lead Sponsor
- Hospices Civils de Lyon
- Target Recruit Count
- 20
- Registration Number
- NCT01246180
- Locations
- 🇫🇷
Pôle d'activité medicale-Centre Hospitalier Lyon Sud-Hospices Civils de Lyon, Pierre Bénite, France
Treatment of Coronary Heart Disease With Amiloride
- Conditions
- Interventions
- First Posted Date
- 2010-11-01
- Last Posted Date
- 2012-06-11
- Lead Sponsor
- University of Carabobo
- Target Recruit Count
- 70
- Registration Number
- NCT01231165
- Locations
- 🇻🇪
Hypertension Research Unit, Valencia, Carabobo, Venezuela
Novel Treatment for Coronary Artery Disease
- First Posted Date
- 2010-10-26
- Last Posted Date
- 2013-03-19
- Lead Sponsor
- University of Carabobo
- Target Recruit Count
- 100
- Registration Number
- NCT01228214
- Locations
- 🇻🇪
Hypertension Research Unit, Valencia, Carabobo, Venezuela
The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables
- Conditions
- Interventions
- First Posted Date
- 2010-09-06
- Last Posted Date
- 2015-08-20
- Lead Sponsor
- Regional Hospital Holstebro
- Target Recruit Count
- 25
- Registration Number
- NCT01195805
- Locations
- 🇩🇰
Departments of medical research and medicine, Holstebro, Denmark
Do Acid Sensing Ion Channels Contribute to Heartburn?
- Conditions
- Interventions
- First Posted Date
- 2010-03-30
- Last Posted Date
- 2012-09-20
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 24
- Registration Number
- NCT01095133
- Locations
- 🇺🇸
The Clinical and Translational Research Center, Chapel Hill, North Carolina, United States
The Effect of Amiloride and Spironolactone in Healthy Persons
- Conditions
- Interventions
- First Posted Date
- 2009-03-09
- Last Posted Date
- 2011-07-08
- Lead Sponsor
- Regional Hospital Holstebro
- Target Recruit Count
- 30
- Registration Number
- NCT00857909
- Locations
- 🇩🇰
Medical Research, Holstebro, Denmark
Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension
- First Posted Date
- 2008-07-03
- Last Posted Date
- 2014-05-28
- Lead Sponsor
- VA Salt Lake City Health Care System
- Registration Number
- NCT00709137
- Locations
- 🇺🇸
VAMC SLC - George Wahlen VA, SLC, Utah, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.