Hydrochlorothiazide
- Generic Name
- Hydrochlorothiazide
- Brand Names
- Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8ClN3O4S2
- CAS Number
- 58-93-5
- Unique Ingredient Identifier
- 0J48LPH2TH
- Background
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II rec...
- Indication
Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.
- Associated Conditions
- Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke
- Associated Therapies
- -
Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension
- Conditions
- Interventions
- First Posted Date
- 2016-01-05
- Last Posted Date
- 2016-01-05
- Lead Sponsor
- Shanghai Changzheng Hospital
- Target Recruit Count
- 508
- Registration Number
- NCT02646397
- Locations
- 🇨🇳
Department of Nephrology, Shanghai Changzheng Hospital, Shanghai, Shanghai, China
RAS Peptide Profiles in Patients With Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-05-20
- Last Posted Date
- 2019-02-22
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 107
- Registration Number
- NCT02449811
- Locations
- 🇨🇭
University Hospital, Basel, Switzerland
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2018-11-15
- Target Recruit Count
- 42
- Registration Number
- NCT02412761
- Locations
- 🇺🇸
University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics, Houston, Texas, United States
INTERVENCION Trial
- Conditions
- Interventions
- First Posted Date
- 2015-02-26
- Last Posted Date
- 2015-10-21
- Lead Sponsor
- Prevencion
- Target Recruit Count
- 120
- Registration Number
- NCT02373163
- Locations
- 🇵🇪
Centro de Investigacion PREVENCION, Arequipa, AQP, Peru
Safety, Tolerability and Pharmacokinetics of Single Rising and Multiple Oral Doses of Telmisartan / Hydrochlorothiazide (HCTZ) in Healthy Male Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-10-13
- Last Posted Date
- 2023-12-08
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 20
- Registration Number
- NCT02262780
Bioequivalence of Telmisartan/ HCTZ Fixed Dose Combination Compared With Its Monocomponents in Healthy Male Volunteers II
- First Posted Date
- 2014-10-13
- Last Posted Date
- 2014-10-13
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 68
- Registration Number
- NCT02262858
Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population
- Conditions
- Interventions
- First Posted Date
- 2014-10-02
- Last Posted Date
- 2015-03-11
- Lead Sponsor
- The George Institute for Global Health, China
- Target Recruit Count
- 1410
- Registration Number
- NCT02255253
- Locations
- 🇨🇳
Chinese Traditional Medicine Hospital of Anguo, Baoding, Hebei, China
🇨🇳Lixian chinese traditional medicine hospital, Baoding, Hebei, China
🇨🇳People's hospital in Rongcheng, Baoding, Hebei, China
A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide
- Conditions
- Interventions
- First Posted Date
- 2014-08-21
- Last Posted Date
- 2016-07-01
- Lead Sponsor
- Boryung Pharmaceutical Co., Ltd
- Target Recruit Count
- 103
- Registration Number
- NCT02222480
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Treatment of Hypertension in Tibetan Adult Population
- Conditions
- Interventions
- First Posted Date
- 2014-08-15
- Last Posted Date
- 2014-08-29
- Lead Sponsor
- West China Hospital
- Target Recruit Count
- 800
- Registration Number
- NCT02217852
- Locations
- 🇨🇳
West China Hospital, Chengdu, Sichuan, China
Relative Oral Bioavailability of Telmisartan / Hydrochlorothiazide (HCTZ) Fixed Dose Combination (FDC) Compared With Its Monocomponents in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2014-07-11
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 32
- Registration Number
- NCT02187523
Drug Development Updates
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