Hydrochlorothiazide

Generic Name
Hydrochlorothiazide
Brand Names
Accuretic, Actelsar Hct, Aldactazide, Altace HCT, Atacand, Atacand Hct, Avalide, Benicar Hct, Diovan Hct, Exforge Hct, Hyzaar, Ifirmacombi, Karvezide, Lopressor Hct, Lotensin Hct, Maxzide, Micardis-hct, Olmetec Plus, Tekturna Hct, Teveten HCT, Tribenzor, Urozide, Vaseretic, Viskazide, Zestoretic, Ziac
Drug Type
Small Molecule
Chemical Formula
C7H8ClN3O4S2
CAS Number
58-93-5
Unique Ingredient Identifier
0J48LPH2TH
Background

Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors or angiotensin II rec...

Indication

Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy. Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.

Associated Conditions
Calcium Nephrolithiasis, Cirrhosis of the Liver, Congestive Heart Failure (CHF), Diabetes Insipidus, Edema, Hypertension, Hypertension, Essential Hypertension, Hypokalemia caused by diuretics, Nephrotic Syndrome, Pre-Eclampsia, Premenstrual tension with edema, Renal tubular acidosis, Sodium retention, Stroke
Associated Therapies
-
Clinical Trials
Related News

A Study to Evaluate the Drug-drug Interaction Between Telmisartan, Amlodipine and Hydrochlorothiazide

First Posted Date
2019-03-26
Last Posted Date
2019-03-26
Lead Sponsor
IlDong Pharmaceutical Co Ltd
Target Recruit Count
30
Registration Number
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Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

First Posted Date
2018-04-27
Last Posted Date
2024-12-17
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Target Recruit Count
1600
Registration Number
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Locations
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Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States

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Loma Linda University Health, Loma Linda, California, United States

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Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide

Recruiting
Conditions
Obesity, Morbid
First Posted Date
2018-03-26
Last Posted Date
2023-04-13
Lead Sponsor
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Target Recruit Count
12
Registration Number
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Locations
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N-of-1 Trials In Children With Hypertension

First Posted Date
2018-03-09
Last Posted Date
2022-09-09
Lead Sponsor
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49
Registration Number
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Locations
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The University of Texas Health Science Center at Houston, Houston, Texas, United States

A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide

First Posted Date
2018-01-02
Last Posted Date
2022-04-25
Lead Sponsor
Sanofi
Target Recruit Count
16
Registration Number
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ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

First Posted Date
2017-09-28
Last Posted Date
2024-05-08
Lead Sponsor
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213
Registration Number
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First Posted Date
2017-09-08
Last Posted Date
2017-09-11
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Registration Number
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Pharmacogenomics of Hypertension Personalized Medicine (PGX-HT)

Phase 3
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Interventions
Drug: Peri
Drug: HCTZ
First Posted Date
2017-08-15
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2017-08-15
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Azienda Ospedaliero - Universitaria S. Maria della Misericordia, Udine, Italy

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Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans

First Posted Date
2017-06-07
Last Posted Date
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Registration Number
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Pennsylvania State University, University Park, Pennsylvania, United States

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein

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