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Perindopril

Generic Name
Perindopril
Brand Names
Aceon, Coversyl, Prestalia, Viacoram
Drug Type
Small Molecule
Chemical Formula
C19H32N2O5
CAS Number
82834-16-0
Unique Ingredient Identifier
Y5GMK36KGY
Background

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.

Indication

For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.

Associated Conditions
Cardiovascular Events, Diabetic Nephropathy, Hypertension, Hypertension, Essential Hypertension, Myocardial Infarction, NYHA Class I Congestive heart failure, Stroke, Chronic heart failure with reduced ejection fraction (NYHA Class II), Chronic heart failure with reduced ejection fraction (NYHA Class III)
Clinical Trials
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Timely Recovery After Subclinical Heart Failure

Phase 4
Recruiting
Conditions
Diastolic Dysfunction
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First Posted Date
2024-04-02
Last Posted Date
2024-04-02
Lead Sponsor
Academisch Ziekenhuis Maastricht
Target Recruit Count
130
Registration Number
NCT06341101
Locations
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AZMaastricht, Maastricht, Limburg, Netherlands

Bioequivalence Study of Perindopril Tablets in Healthy Volunteers Under Fasting Conditions

Phase 1
Recruiting
Conditions
Bioequivalence
Interventions
Drug: Prestarium® A tablet
First Posted Date
2024-01-19
Last Posted Date
2024-01-19
Lead Sponsor
Pharmtechnology LLC
Target Recruit Count
50
Registration Number
NCT06213610
Locations
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Ligand Research LLC, Moscow, Russian Federation

Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India

First Posted Date
2023-01-13
Last Posted Date
2024-10-08
Lead Sponsor
Centre for Chronic Disease Control, India
Target Recruit Count
1981
Registration Number
NCT05683301
Locations
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Apollo Hospitals, Bhubaneshwar, Odisha, India

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Assam Medical College, Dibrugarh, Assam, India

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Indraprastha Apollo Hospitals, New Delhi, Delhi, India

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Precision Treatment With Angiotensin Converting Enzyme Inhibitor

Phase 4
Completed
Conditions
Hypertension
Interventions
Drug: genotyping and selection of renin-angiotensin system blocker
First Posted Date
2022-09-10
Last Posted Date
2023-01-11
Lead Sponsor
Yonsei University
Target Recruit Count
77
Registration Number
NCT05535595
Locations
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Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of

Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia

Phase 3
Terminated
Conditions
Dyslipidemias
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First Posted Date
2020-10-19
Last Posted Date
2023-10-18
Lead Sponsor
Institut de Recherches Internationales Servier
Target Recruit Count
146
Registration Number
NCT04591808
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Medical center ''CONSILIUM MEDICAL'', Kyiv, Ukraine

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Private Small-Scale Enterprise Medical Center "Pulse", Vinnytsya, Ukraine

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Saint Petersburg state budgetary institution of healthcare "City policlinic #109", Saint Petersburg, Russian Federation

and more 40 locations

A Study on the Bioequivalence of Perindopril Tert-butylamine Tablets Taken on After Meals in Healthy Subjects

First Posted Date
2020-09-21
Last Posted Date
2020-09-21
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
32
Registration Number
NCT04556110
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General Hospital of the northern theater of the Chinese people's Liberation Army, Shenyang, Liaoning, China

A Study on the Bioequivalence of Perindopril Tert-butylamine Tablets Taken on an Empty Stomach in Healthy Subjects

First Posted Date
2020-09-21
Last Posted Date
2020-09-21
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
32
Registration Number
NCT04556058
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🇨🇳

General Hospital of the northern theater of the Chinese people's Liberation Army, Shenyang, Liaoning, China

Early Treatment of ARNI on Myocardial Remodeling and Progress

Phase 4
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Interventions
Other: Cardiopulmonary Exercise Test
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First Posted Date
2020-04-13
Last Posted Date
2020-04-14
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Target Recruit Count
280
Registration Number
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RenJi Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, Shanghai, China

Comparative Effects of Perindopril and Zofenopril on Blood Pressure Control and Oxidative Status Blacks Hypertensive Patients.

Phase 4
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Conditions
Hypertension
Interventions
Drug: Zofenopril, Calcium Salt, (1(R*),2Alpha,4Alpha)-isomer
First Posted Date
2020-02-05
Last Posted Date
2020-02-05
Lead Sponsor
Yaounde Central Hospital
Target Recruit Count
24
Registration Number
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Locations
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Yaounde Central Hospital, Cardiology department, Yaounde, Cameroon

Evaluation of Losartan and Perindopril in Blacks Type 2 Diabetics Patients

Phase 4
Completed
Conditions
Type 2 Diabetes Mellitus
Interventions
First Posted Date
2020-01-10
Last Posted Date
2020-01-10
Lead Sponsor
Yaounde Central Hospital
Target Recruit Count
23
Registration Number
NCT04222686
Locations
🇨🇲

Yaounde Central Hospital, NAtional Obesity Center, Yaounde, Cameroon

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