Edetic acid

Overview

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Background

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Indication

For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.

Associated Conditions

Lead Poisoning
Toxic encephalopathy

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract	2024/04/15	NCT06365762	Phase 1	Completed	Livionex Inc.
EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions	2021/05/19	NCT04893577	Phase 2	ENROLLING_BY_INVITATION	University of Utah
Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis	2019/08/05	NCT04044417	Phase 4	Completed	Ain Shams University
A Pilot Study to Assess the Preliminary Efficacy of EDTA Eye Drops on Band Keratopathy	2019/06/13	NCT03985371	Early Phase 1	Completed	University of Rochester
Chelation Therapy in Diabetic Patients With Critical Limb Ischemia	2018/02/07	NCT03424746	Early Phase 1	Completed	Mt. Sinai Medical Center, Miami
Trial to Assess Chelation Therapy 2	2016/04/11	NCT02733185	Phase 3	Completed	Mt. Sinai Medical Center, Miami
Evaluation of Bacterial and Fungal Contamination During Propofol Continuous Infusion	2008/09/23	NCT00757458	Not Applicable	UNKNOWN	University of Sao Paulo
Environmental Exposure to Lead and Progressive Renal Insufficiency in Type II Diabetic Nephropathy	2005/10/13	NCT00237952	Not Applicable	Completed	Chang Gung Memorial Hospital
Trial to Assess Chelation Therapy (TACT)	2002/08/23	NCT00044213	Phase 3	Completed	Mt. Sinai Medical Center, Miami

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

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