Fisetin

Generic Name: Fisetin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₀O_₆

CAS Number: 528-48-3

Unique Ingredient Identifier: OO2ABO9578

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity

Phase 1

Not yet recruiting

Conditions: Healthy
Multimorbidity

Interventions: Drug: Fisetin
Drug: Placebo

First Posted Date: 2024-05-29

Last Posted Date: 2024-08-28

Lead Sponsor: Ove Andersen

Target Recruit Count: 60

Registration Number: NCT06431932

Fisetin to Reduce Senescence and Mobility Impairment in PAD

Phase 2

Recruiting

Conditions: Peripheral Arterial Disease
Aging
Peripheral Vascular Diseases
Walking, Difficulty
Claudication

Interventions: Drug: Placebo
Drug: Fisetin

First Posted Date: 2024-05-06

Last Posted Date: 2024-10-08

Lead Sponsor: Northwestern University

Target Recruit Count: 34

Registration Number: NCT06399809

Locations: 🇺🇸
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

Prevention of Frailty with Fisetin and Exercise (PROFFi) in Breast Cancer Survivors

Phase 2

Recruiting

Conditions: Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) V8
Anatomic Stage II Breast Cancer AJCC V8
Anatomic Stage III Breast Cancer AJCC V8
Early Stage Breast Carcinoma

Interventions: Procedure: Biospecimen Collection
Other: Educational Intervention
Other: Exercise Intervention
Drug: Fisetin
Other: Physical Performance Testing
Drug: Placebo Administration
Other: Quality-of-Life Assessment
Other: Questionnaire Administration

First Posted Date: 2023-11-02

Last Posted Date: 2024-12-20

Lead Sponsor: Jonsson Comprehensive Cancer Center

Target Recruit Count: 164

Registration Number: NCT06113016

Locations: 🇺🇸
UCLA Health Cancer Care in Alhambra, Alhambra, California, United States
🇺🇸
UCLA Health Beverly Hills Primary & Specialty Care, Beverly Hills, California, United States
🇺🇸
UCLA Health Burbank Primary & Specialty Care, Burbank, California, United States

and more 3 locations

Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

Phase 2

Recruiting

Conditions: Anatomic Stage I Breast Cancer AJCC V8
Anatomic Stage II Breast Cancer AJCC V8
Anatomic Stage III Breast Cancer AJCC V8

Interventions: Procedure: Biospecimen Collection
Drug: Placebo Administration
Drug: Fisetin
Other: Quality-of-Life Assessment
Other: Questionnaire Administration

First Posted Date: 2022-10-27

Last Posted Date: 2024-12-19

Lead Sponsor: Jonsson Comprehensive Cancer Center

Target Recruit Count: 88

Registration Number: NCT05595499

Locations: 🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States
🇺🇸
UCLA Health Cancer Care in Alhambra, Alhambra, California, United States
🇺🇸
UCLA Health Beverly Hills Primary & Specialty Care, Beverly Hills, California, United States

and more 4 locations

Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency

Phase 2

Conditions: Common Variable Immunodeficiency
Interstitial Lung Disease Due to Systemic Disease

Interventions: Drug: Placebo
Drug: Fisetin

First Posted Date: 2022-10-25

Last Posted Date: 2024-04-26

Lead Sponsor: Avni Joshi

Target Recruit Count: 20

Registration Number: NCT05593588

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair

Phase 2

Not yet recruiting

Conditions: Meniscus Tear
Meniscus; Derangement
Meniscus Lesion
Meniscus Disorder

Interventions: Drug: Placebo oral capsule
Drug: Fisetin

First Posted Date: 2022-08-18

Last Posted Date: 2024-04-19

Lead Sponsor: Austin V Stone

Target Recruit Count: 38

Registration Number: NCT05505747

Locations: 🇺🇸
UK Healthcare at Turfland, Lexington, Kentucky, United States

GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression

Phase 2

Withdrawn

Conditions: Knee Osteoarthritis
Obese
Depression

Interventions: Drug: Placebo oral capsule
Drug: Fisetin
Behavioral: GetHealthy-OA mind-body program
Behavioral: Health education booklet

First Posted Date: 2022-08-01

Last Posted Date: 2023-05-01

Lead Sponsor: Cale Andrew Jacobs, PhD

Registration Number: NCT05482672

Locations: 🇺🇸
UK HealthCare Joint Reconstruction and Replacement, Lexington, Kentucky, United States
🇺🇸
UK Healthcare at Turfland, Lexington, Kentucky, United States

A Study of Fisetin to Treat Carpal Tunnel Syndrome

Phase 2

Active, not recruiting

Conditions: Carpal Tunnel Syndrome

Interventions: Drug: Fisetin

First Posted Date: 2022-06-13

Last Posted Date: 2024-10-02

Lead Sponsor: Peter C. Amadio, M.D.

Target Recruit Count: 40

Registration Number: NCT05416515

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Senolytic Agent Improve the Benefit of Platelet-Rich Plasma and Losartan

Phase 1

Active, not recruiting

Conditions: Femoroacetabular Impingement

Interventions: Drug: Placebo
Drug: Fisetin

First Posted Date: 2021-08-30

Last Posted Date: 2024-04-16

Lead Sponsor: Steadman Philippon Research Institute

Target Recruit Count: 68

Registration Number: NCT05025956

Locations: 🇺🇸
The Steadman Clinic, Vail, Colorado, United States

Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis

Phase 1

Active, not recruiting

Conditions: Osteoarthritis, Knee

Interventions: Drug: Placebo - Losartan
Drug: Fisetin
Drug: Placebo Fisetin
Drug: Losartan

First Posted Date: 2021-03-25

Last Posted Date: 2024-04-16

Lead Sponsor: Steadman Philippon Research Institute

Target Recruit Count: 100

Registration Number: NCT04815902

Locations: 🇺🇸
The Steadman Clinic, Vail, Colorado, United States

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