Fisetin

Opportunities on campus include stress coping study (up to $470), part-time jobs in Student Affairs and Dining Services, POTS study (up to $446), sleep studies (up to $3,785), MS clinical trial (up to $880), cardiovascular research, bipolar disorder study (up to $400), bioastronautics research ($15/hour), chronic back pain study (up to $360), CBD mood health study (up to $1,038), and child communication research.

The clinical primary endpoint is the difference in CRR-SOFA score at baseline and 7 days (ΔCRR-SOFA7), analyzed in a Bayesian paradigm to guide response-adaptive randomization. A Bayesian model jointly models ΔCRR-SOFA7 and organ failure-free days (OFFD28) for interim monitoring. ΔCRR-SOFA7 is modeled as normally distributed, and OFFD28 using a proportional odds logistic regression. Priors are set for model parameters, and posterior distributions approximated via Gibbs Sampling. Interim analyses at 100 and 180 participants determine trial continuation based on predictive probabilities. Secondary analyses include linear regression and mixed models adjusting for covariates. Secondary endpoints are summarized and compared using regression and proportional odds logistic regression. Biologic endpoints are analyzed similarly, with adjustments for potential confounders. Interim analyses consider predictive probabilities of success in future trials. Subgroup analyses explore treatment effects across defined subgroups. Missing data is handled through data augmentation and multiple imputation. Data sharing is considered on a case-by-case basis.