Hyaluronidase
- Generic Name
- Hyaluronidase
- Brand Names
- Amphadase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9001-54-1
- Unique Ingredient Identifier
- 8KOG53Z5EM
- Background
Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. Hyaluro...
- Indication
Hyaluronidase is indicated for subcutaneous fluid administration for hydration, and increasing resorption of radiopaque agents in subcutaneous urography. Hyaluronidase is also indicated by multiple routes to increase the dispersion of other injectable drugs.
- Associated Conditions
- -
- Associated Therapies
- Parenteral rehydration therapy, Parenteral drug administration, Subcutaneous urography
Hyaluronidase Assisted Subcutaneous Infusion
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-09-19
- Lead Sponsor
- Shanghai Bao Pharmaceuticals Co., Ltd.
- Target Recruit Count
- 45
- Registration Number
- NCT06604546
- Locations
- 🇨🇳
Suzhou Municipal Hospital, Su Zhou, Jiangsu, China
Hyaluronidase Via LADD Scleroderma-induced Microstomia
- Conditions
- Interventions
- First Posted Date
- 2023-08-16
- Last Posted Date
- 2024-10-16
- Lead Sponsor
- University of Nebraska
- Target Recruit Count
- 10
- Registration Number
- NCT05995626
- Locations
- 🇺🇸
University of Nebraska Medical Center, Lauritzen Outpatient Center, Omaha, Nebraska, United States
🇺🇸Nebraska Medicine, Dermatology Westroads, Omaha, Nebraska, United States
Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2023-01-04
- Last Posted Date
- 2023-07-27
- Lead Sponsor
- Benha University
- Target Recruit Count
- 90
- Registration Number
- NCT05671172
- Locations
- 🇪🇬
Samar Rafik Amin, Banhā, Qalubia, Egypt
Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma
- Conditions
- Interventions
- First Posted Date
- 2022-08-11
- Last Posted Date
- 2024-03-05
- Lead Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Target Recruit Count
- 44
- Registration Number
- NCT05498220
- Locations
- 🇺🇸
Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States
A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer.
- Conditions
- Interventions
- First Posted Date
- 2022-01-25
- Last Posted Date
- 2023-08-15
- Lead Sponsor
- Epizyme, Inc.
- Registration Number
- NCT05205252
- Locations
- 🇺🇸
Central Care Cancer Center, Bolivar, Missouri, United States
🇺🇸California Cancer Associates For Research And Excellence, cCARE, Santa Fe, California, United States
🇺🇸Astera Cancer Center, East Brunswick, New Jersey, United States
Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block
- First Posted Date
- 2021-10-19
- Last Posted Date
- 2021-10-27
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 40
- Registration Number
- NCT05083663
- Locations
- 🇪🇬
Sohag University Hospital, Sohag, Egypt
Ultrasound Guided Erector Spinae Plane Block in Breast Surgery
- First Posted Date
- 2018-09-06
- Last Posted Date
- 2020-04-09
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT03660020
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study
- Conditions
- Interventions
- First Posted Date
- 2018-01-26
- Last Posted Date
- 2018-04-27
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 64
- Registration Number
- NCT03411330
- Locations
- 🇪🇬
Ahmed Abdalla Mohamed, Cairo, Egypt
Peripheral Modulation of Muscle Stiffness and Spasticity
- First Posted Date
- 2017-10-11
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 56
- Registration Number
- NCT03306615
- Locations
- 🇺🇸
Johns Hopkins School of Medicine, Baltimore, Maryland, United States
Effect of Hyaluronidase on Intraocular Pressure
- First Posted Date
- 2017-08-30
- Last Posted Date
- 2017-08-30
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 50
- Registration Number
- NCT03266406
Drug Development Updates
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