Ivermectin
- Generic Name
- Ivermectin
- Brand Names
- Sklice, Soolantra, Stromectol
- Drug Type
- Small Molecule
- Chemical Formula
- C95H146O28
- CAS Number
- 70288-86-7
- Unique Ingredient Identifier
- 8883YP2R6D
- Background
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A (22,23-dihydroavermectin B) and 10%...
- Indication
Administered topically, ivermectin cream is indicated for the treatment of inflammatory lesions associated with rosacea. An over-the-counter ivermection lotion is commercially available and indicated for the topical treatment of head lice infestations in patients ≥6 months of age.
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- Associated Conditions
- Ascariasis, Demodex Infestation, Enterobiasis, Filariasis caused by Loa Loa, Gnathostomiasis, Head Lice Infestation, Malaria, Myiasis, Onchocerciasis caused by Infection with Onchocerca volvulus, Rosacea, Scabies, Strongyloidiasis caused by Strongyloides Stercoralis Infection, Trichuriasis
- Associated Therapies
- -
Efficacy of Ivermectin in COVID-19
- Conditions
- Interventions
- First Posted Date
- 2021-10-13
- Last Posted Date
- 2021-12-15
- Target Recruit Count
- 72
- Registration Number
- NCT05076253
- Locations
- 🇹🇭
Thananda Trakarnvanich, Bangkok, Thailand
Prophylaxis of COVID-19 Disease With Ivermectin in COVID-19 Contact Persons [German: Prophylaxe Der COVID-19-Erkrankung Mit Ivermectin Bei COVID-19 Kontaktpersonen]
- First Posted Date
- 2021-09-29
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- Infectopharm Arzneimittel GmbH
- Target Recruit Count
- 412
- Registration Number
- NCT05060666
Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19
- First Posted Date
- 2021-09-16
- Last Posted Date
- 2022-04-27
- Lead Sponsor
- Patrick Robinson
- Target Recruit Count
- 1000
- Registration Number
- NCT05045937
- Locations
- 🇺🇸
Patrick Robinson MD LLC, San Antonio, Florida, United States
Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
- Conditions
- Interventions
- Drug: Nirmatrelvir/ritonavir (e.g. PAXLOVID™)Drug: NitazoxanideDrug: Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)Drug: HydroxychloroquineOther: No treatmentDrug: Monoclonal antibodiesDrug: FluoxetineDrug: MolnupiravirDrug: SotrovimabDrug: EnsitrelvirDrug: FavipiravirDrug: IvermectinDrug: RemdesivirDrug: Atilotrelvir/ritonavirDrug: MetforminDrug: Nirmatrelvir/ritonavirDrug: Nirmatrelvir
- First Posted Date
- 2021-09-13
- Last Posted Date
- 2024-10-28
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 3800
- Registration Number
- NCT05041907
- Locations
- 🇳🇵
Sukraraj Tropical & Infectious Disease Hospital, Kathmandu, Nepal
🇧🇷Universidade Federal de Minas Gerais, Minas Gerais, Brazil
🇱🇦Laos-Oxford-Mahosot Wellcome Trust Research Unit, Vientiane, Lao People's Democratic Republic
Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
- First Posted Date
- 2021-09-10
- Last Posted Date
- 2021-09-10
- Lead Sponsor
- Raincy Montfermeil Hospital Group
- Target Recruit Count
- 200
- Registration Number
- NCT05040724
- Locations
- 🇫🇷
GHI Le Raincy Montfermeil, Montfermeil, France
Remdesivir- Ivermectin Combination Therapy in Severe Covid-19
- First Posted Date
- 2021-06-29
- Last Posted Date
- 2021-06-29
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT04944082
Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)
- First Posted Date
- 2021-05-20
- Last Posted Date
- 2021-12-07
- Lead Sponsor
- Ministry of Public Health, Argentina
- Target Recruit Count
- 172
- Registration Number
- NCT04894721
- Locations
- 🇦🇷
SI.PRO.SA, Ministerio de Salud Pública, Tucumán, Argentina
The Zambia Ivermectin Trial for the Treatment and Prevention of COVID-19
- First Posted Date
- 2021-05-18
- Last Posted Date
- 2022-02-03
- Lead Sponsor
- Centre for Infectious Disease Research in Zambia
- Registration Number
- NCT04891250
- Locations
- 🇿🇲
University of Zambia, Lusaka, Zambia
Ivermectina Colombia (IVERCOL)
- First Posted Date
- 2021-05-14
- Last Posted Date
- 2021-05-14
- Lead Sponsor
- Ayudas Diagnosticas Sura S.A.S
- Target Recruit Count
- 966
- Registration Number
- NCT04886362
ACTIV-6: COVID-19 Study of Repurposed Medications
- Conditions
- Interventions
- First Posted Date
- 2021-05-13
- Last Posted Date
- 2024-11-13
- Lead Sponsor
- Susanna Naggie, MD
- Target Recruit Count
- 10956
- Registration Number
- NCT04885530
- Locations
- 🇺🇸
Emory Healthcare, Atlanta, Georgia, United States
🇺🇸Northwestern Univesity, Chicago, Illinois, United States
🇺🇸Rush University Medical Center, Chicago, Illinois, United States
Drug Development Updates
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