Fluorouracil

Generic Name
Fluorouracil
Brand Names
Actikerall, Carac, Efudex, Fluoroplex, Tolak
Drug Type
Small Molecule
Chemical Formula
C4H3FN2O2
CAS Number
51-21-8
Unique Ingredient Identifier
U3P01618RT
Background

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions
Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
Associated Therapies
-

Combination Chemotherapy Plus Cetuximab in Treating Patients With Liver Metastases From Colorectal Cancer

First Posted Date
2003-03-07
Last Posted Date
2017-01-24
Lead Sponsor
Alliance for Clinical Trials in Oncology
Target Recruit Count
73
Registration Number
NCT00056030
Locations
🇺🇸

Mayo Clinic Scottsdale, Scottsdale, Arizona, United States

🇺🇸

CCOP - Upstate Carolina, Spartanburg, South Carolina, United States

🇺🇸

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States

and more 155 locations

Safety of GM-CT-01 With and Without 5-Fluorouracil in Patients With Solid Tumors

First Posted Date
2003-02-17
Last Posted Date
2012-03-12
Lead Sponsor
Galectin Therapeutics Inc.
Target Recruit Count
40
Registration Number
NCT00054977
Locations
🇺🇸

Florida Oncology Associates, Jacksonville, Florida, United States

🇺🇸

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

🇺🇸

Ochsner Cancer Institute, New Orleans, Louisiana, United States

and more 1 locations

Tezacitabine With or Without 5-Fluorouracil (5-FU) for Advanced Esophageal Cancer or Gastric Cancer

First Posted Date
2003-02-13
Last Posted Date
2006-07-11
Lead Sponsor
Chiron Corporation
Registration Number
NCT00054873
Locations
🇺🇸

Tower Hematology Oncology Medical Group, Los Angeles, California, United States

🇺🇸

Washington University School of Medicine, St. Louis, Missouri, United States

🇺🇸

The University of Chicago, Chicago, Illinois, United States

and more 26 locations

Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer

First Posted Date
2003-02-06
Last Posted Date
2013-07-19
Lead Sponsor
UNICANCER
Target Recruit Count
3010
Registration Number
NCT00054587
Locations
🇫🇷

Centre Hospitalier de Mulhouse, Mulhouse, France

🇫🇷

Institut Prive de Cancerologie, Grenoble, France

🇫🇷

Centre Paul Papin, Angers, France

and more 26 locations

Interleukin-2, Interferon Alfa, and Fluorouracil Compared With Observation in Treating Patients Who Have Undergone Surgery for Kidney Cancer

Phase 3
Completed
Conditions
First Posted Date
2003-02-06
Last Posted Date
2012-09-24
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Target Recruit Count
96
Registration Number
NCT00053807
Locations
🇳🇱

Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands

🇹🇷

Dokuz Eylul University School of Medicine, Izmir, Turkey

🇳🇱

Daniel Den Hoed Cancer Center at Erasmus University Medical Center, Rotterdam, Netherlands

and more 14 locations

S0216, Combination Chemotherapy and RT in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Phase 2
Completed
Conditions
First Posted Date
2003-02-06
Last Posted Date
2011-07-25
Lead Sponsor
SWOG Cancer Research Network
Registration Number
NCT00054054
Locations
🇺🇸

MBCCOP - Gulf Coast, Mobile, Alabama, United States

🇺🇸

CCOP - Atlanta Regional, Atlanta, Georgia, United States

🇺🇸

Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago, Illinois, United States

and more 92 locations

Combination Chemotherapy Compared With Observation After Surgery in Treating Women With Relapsed Nonmetastatic Breast Cancer

Phase 3
Terminated
Conditions
First Posted Date
2003-02-06
Last Posted Date
2014-12-16
Lead Sponsor
UNICANCER
Registration Number
NCT00053911
Locations
🇫🇷

Clinique Claude Bernard, Albi, France

🇫🇷

Institut Bergonie, Bordeaux, France

🇫🇷

Centre Paul Papin, Angers, France

and more 23 locations

Interferon Alfa With or Without Interleukin-2 and Fluorouracil in Treating Patients With Advanced Metastatic Kidney Cancer

Phase 3
Completed
Conditions
First Posted Date
2003-02-06
Last Posted Date
2013-12-19
Lead Sponsor
Medical Research Council
Target Recruit Count
670
Registration Number
NCT00053820
Locations
🇳🇱

Leiden University Medical Center, Leiden, Netherlands

🇳🇱

Academisch Ziekenhuis Maastricht, Maastricht, Netherlands

🇧🇪

Onze Lieve Vrouw Ziekenhuis Aalst, Aalst, Belgium

and more 9 locations

Fluorouracil, Gemcitabine, and Radiation Therapy in Treating Patients With Cancer of the Pancreas

Phase 3
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-11-19
Lead Sponsor
Radiation Therapy Oncology Group
Target Recruit Count
518
Registration Number
NCT00003216
Locations
🇺🇸

CCOP - Duluth, Duluth, Minnesota, United States

🇺🇸

Veterans Affairs Medical Center - West Los Angeles, Los Angeles, California, United States

🇺🇸

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

and more 104 locations

Radiation Therapy Alone Compared to Radiation Therapy Plus Chemotherapy in Treating Patients With Previously Untreated Cancer of the Nasopharynx

Phase 3
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-12-19
Lead Sponsor
National Cancer Centre, Singapore
Target Recruit Count
200
Registration Number
NCT00003637
Locations
🇸🇬

National Cancer Centre - Singapore, Singapore, Singapore

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