Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including ...
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Combination Chemotherapy With or Without Colony-stimulating Factors in Treating Women With Breast Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2020-10-05
- Lead Sponsor
- NCIC Clinical Trials Group
- Target Recruit Count
- 2104
- Registration Number
- NCT00014222
- Locations
- 🇺🇸
Sparks-Arkansas Oklahoma Cancer Treatment Centre, Fort Smith, Arkansas, United States
🇺🇸Maine Center for Cancer Medicine and Blood Disorders, Scarborough, Maine, United States
🇺🇸The University of Chicago Medical Center, Chicago, Illinois, United States
Erlotinib and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-24
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT00049101
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-05-30
- Lead Sponsor
- Intracel
- Registration Number
- NCT00016133
- Locations
- 🇺🇸
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown, Pennsylvania, United States
🇺🇸Inova Fairfax Hospital, Fairfax, Virginia, United States
Radiation Therapy and Fluorouracil Before Surgery in Treating Patients With Primary or Recurrent Bile Duct Cancer
- Conditions
- Locations
- 🇧🇪
Les Cliniques Saint-Joseph ASBL, Liege, Belgium
🇺🇸Cancer Center at the University of Virginia, Charlottesville, Virginia, United States
🇧🇪Hopital de Jolimont, Haine Saint Paul, Belgium
Combination Chemotherapy Plus Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Esophagus or Stomach
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-07-19
- Lead Sponsor
- Radiation Therapy Oncology Group
- Registration Number
- NCT00009880
- Locations
- 🇺🇸
Memorial Hospital of South Bend, South Bend, Indiana, United States
🇺🇸Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States
🇺🇸Mount Carmel West Hospital, Columbus, Ohio, United States
Radiation Therapy Plus Chemotherapy in Treating Patients With Pancreatic Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-07-18
- Lead Sponsor
- Center for Molecular Medicine
- Target Recruit Count
- 48
- Registration Number
- NCT00002689
- Locations
- 🇺🇸
Northside Hospital Cancer Center, Atlanta, Georgia, United States
🇺🇸Center for Molecular Medicine, Garden City, New York, United States
UCN-01 and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-24
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT00045747
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- National Cancer Institute (NCI)
- Registration Number
- NCT00039611
- Locations
- 🇺🇸
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸St. Vincent Hospital and Health Center, Billings, Montana, United States
🇺🇸Mayo Clinic, Jacksonville, Florida, United States
Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-14
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 277
- Registration Number
- NCT00003994
- Locations
- 🇺🇸
Children's Oncology Group, Arcadia, California, United States
Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-05
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 32
- Registration Number
- NCT00052559
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Drug Development Updates
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