Debrisoquine
- Generic Name
- Debrisoquine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N3
- CAS Number
- 1131-64-2
- Unique Ingredient Identifier
- X31CDK040E
- Background
An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
- Indication
For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
- Associated Conditions
- -
- Associated Therapies
- -
No trials found
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