Debrisoquine
- Generic Name
- Debrisoquine
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N3
- CAS Number
- 1131-64-2
- Unique Ingredient Identifier
- X31CDK040E
- Background
An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
- Indication
For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Metabolic Capacity of Israeli Populations
Not Applicable
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2005-09-13
- Last Posted Date
- 2018-06-12
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 1200
- Registration Number
- NCT00162383
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel
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