Methacholine
- Generic Name
- Methacholine
- Brand Names
- Provocholine
- Drug Type
- Small Molecule
- Chemical Formula
- C8H18NO2
- CAS Number
- 55-92-5
- Unique Ingredient Identifier
- 03V657ZD3V
- Background
Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty breathing. Although the underlying pathology of AHR is complex, ASM contraction can be stimulated by...
- Indication
Methacholine is indicated in adult and pediatric patients aged five years and older without clinically apparent asthma for the diagnosis of bronchial airway hyperactivity via the methacholine challenge test.
- Associated Conditions
- Bronchial airway hyperreactivity
- Associated Therapies
- -
The Effect of Deep Inhalation on Mannitol Responsiveness
- Conditions
- Interventions
- First Posted Date
- 2018-04-23
- Last Posted Date
- 2019-05-15
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 26
- Registration Number
- NCT03505489
- Locations
- 🇨🇦
Asthma Research Lab - University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Asthma Exacerbations and Vascular Function
- Conditions
- Interventions
- First Posted Date
- 2015-12-15
- Last Posted Date
- 2021-07-01
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 52
- Registration Number
- NCT02630511
- Locations
- 🇨🇦
Clinical Physiology Research Laboratory, Edmonton, Alberta, Canada
Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
- First Posted Date
- 2015-10-14
- Last Posted Date
- 2015-10-16
- Lead Sponsor
- Zhujiang Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT02574975
- Locations
- 🇨🇳
Zhujiang Hospital, Guangzhou, Guangdong, China
Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics
- Conditions
- First Posted Date
- 2005-11-11
- Last Posted Date
- 2009-12-01
- Lead Sponsor
- Syntara
- Target Recruit Count
- 240
- Registration Number
- NCT00252291
- Locations
- 🇺🇸
Colorado Asthma and Allergy Centers, 125 Rampart Way, Denver, Colorado, United States
The Impact of Dosimeter on Measurement of Airway Responsiveness to Methacholine
- Conditions
- First Posted Date
- 2005-09-05
- Last Posted Date
- 2012-03-05
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 12
- Registration Number
- NCT00145990
- Locations
- 🇺🇸
University of Florida Asthma Research Lab, Gainesville, Florida, United States
Drug Development Updates
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