Dutasteride
- Generic Name
- Dutasteride
- Brand Names
- Avodart, Jalyn
- Drug Type
- Small Molecule
- Chemical Formula
- C27H30F6N2O2
- CAS Number
- 164656-23-9
- Unique Ingredient Identifier
- O0J6XJN02I
- Background
Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal mediato...
- Indication
Indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for BPH-related surgery alone or in combination with tamsulosin.
- Associated Conditions
- Benign Prostatic Hyperplasia (BPH), Symptomatic benign prostatic hyperplasia (BPH)
- Associated Therapies
- -
"REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
- First Posted Date
- 2003-03-13
- Last Posted Date
- 2016-09-23
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 8231
- Registration Number
- NCT00056407
- Locations
GSK Investigational Site
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