Allopurinol

Generic Name: Allopurinol

Brand Names: Aloprim, Zyloprim

Drug Type: Small Molecule

Chemical Formula: C_₅H_₄N_₄O

CAS Number: 315-30-0

Unique Ingredient Identifier: 63CZ7GJN5I

Background: Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals .
...

Indication: Allopurinol is indicated in :

1) the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
...

Associated Conditions: Hyperuricemia, Primary Gout, Recurrent calcium oxalate calculi, Secondary gout, Calcium oxalate calculi Renal Calculi

Associated Therapies: -

Clinical Trials

The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure

Not Applicable

Completed

Conditions: Hyperuricemia
Chronic Kidney Disease

Interventions: Drug: allopurinol

First Posted Date: 2009-09-17

Last Posted Date: 2009-09-22

Lead Sponsor: Istanbul University

Target Recruit Count: 20

Registration Number: NCT00978653

Locations: 🇹🇷
Istanbul Faculty of Medicine, Istanbul, Turkey

Prednisone for Heart Failure Patients With Hyperuricemia

Phase 4

Completed

Conditions: Heart Failure
Hyperuricemia

Interventions: Drug: allopurinol
Drug: prednisone

First Posted Date: 2009-06-12

Last Posted Date: 2010-09-01

Lead Sponsor: Hebei Medical University

Target Recruit Count: 40

Registration Number: NCT00919243

Locations: 🇨🇳
Kunshen Liu, Shijiazhuang, Hebei, China

Nonmyeloablative Stem Cell Transplantation for Chronic Lymphocytic Leukemia (CLL)

Phase 2

Terminated

Conditions: Chronic Lymphocytic Leukemia

Interventions: Drug: Lenalidomide
Drug: Fludarabine
Drug: Rituximab
Procedure: Stem Cell Transplantation
Drug: Thymoglobulin
Drug: Bendamustine
Drug: Allopurinol

First Posted Date: 2009-05-12

Last Posted Date: 2020-01-27

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 39

Registration Number: NCT00899431

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Allopurinol in Schizophrenia: A Randomized Trial Administering Allopurinol vs Placebo as add-on Antipsychotics in Patients With Schizophrenia

Phase 4

Completed

Conditions: Schizophrenia
Schizoaffective Disorder

Interventions: Drug: Allopurinol

First Posted Date: 2009-03-19

Last Posted Date: 2012-05-08

Lead Sponsor: Sheba Medical Center

Target Recruit Count: 248

Registration Number: NCT00864825

Locations: 🇮🇱
Sheba Medical Center, Psychiatry Department, Tel Hashomer, Ramat Gan, Israel
🇷🇴
Spitalul Clinic, sectia 8, Berceni st., sector 4 Bucharest, Romania
🇷🇴
Spitalul Clinic de Urgenta Clinica "E. Pamfil" Timisoara, Bd. Iosif Bulbuca, 156, jud timis, Romania

and more 30 locations

A Study of the Efficacy of Canakinumab in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy (Core Study) and a Long-term Study of the Efficacy and Safety of Canakinumab in Patients With Gout (Extension Study)

Phase 2

Completed

Conditions: Gout

Interventions: Drug: Canakinumab
Drug: Allopurinol
Drug: Colchicine
Drug: Placebo Matching Canakinumab
Drug: Placebo Matching Colchicine

First Posted Date: 2009-01-09

Last Posted Date: 2018-07-17

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 432

Registration Number: NCT00819585

Locations: 🇺🇸
Talbert Medical Group, Huntington Beach, California, United States
🇺🇸
Health Awareness, Jupiter, Florida, United States
🇺🇸
East-West Medical Research institute, Honolulu, Hawaii, United States

and more 28 locations

A Controlled Study of Uric Acid on the Progression of IgA Nephropathy

Not Applicable

Completed

Conditions: IgA Nephropathy

Interventions: Other: continue their usual therapy
Drug: allopurinol

First Posted Date: 2008-11-19

Last Posted Date: 2016-05-25

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 40

Registration Number: NCT00793585

Locations: 🇨🇳
The 1st Affiliated Hospital, Sun Yet-sen University, GuangZhou, Guangdong, China

Allopurinol Maintenance Study for Bipolar Disorder

Phase 4

Terminated

Conditions: Bipolar Disorder
Mania
Mixed Mania

Interventions: Drug: Allopurinol

First Posted Date: 2008-08-11

Last Posted Date: 2019-10-02

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 15

Registration Number: NCT00732251

Locations: 🇺🇸
Cedars-Sinai Medical Center, Los Angeles, California, United States

Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction?

Phase 4

Completed

Conditions: Left Ventricular Hypertrophy
Kidney Disease

Interventions: Drug: Placebo
Drug: Allopurinol

First Posted Date: 2008-06-03

Last Posted Date: 2016-11-03

Lead Sponsor: A. D. Struthers

Target Recruit Count: 67

Registration Number: NCT00688480

Locations: 🇬🇧
Division of Medicine and Therapeutics, Ninewells Hospital & Medical School, Dundee, United Kingdom

Allopurinol Add-on Treatment for Refractory Mania

Phase 4

Completed

Conditions: Mixed Mania
Bipolar Disorder
Treatment-Resistant Mania

Interventions: Other: Placebo
Drug: Allopurinol

First Posted Date: 2008-03-26

Last Posted Date: 2019-05-08

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 40

Registration Number: NCT00643123

Locations: 🇺🇸
Cedars-Sinai Medical Center, Los Angeles, California, United States

The Effect of Allopurinol on Insulin Resistance and Blood Pressure

Phase 2

Completed

Conditions: Metabolic Syndrome

Interventions: Drug: Placebo
Drug: Allopurinol

First Posted Date: 2008-03-20

Last Posted Date: 2008-10-13

Lead Sponsor: Hospital Mateo Orfila

Target Recruit Count: 60

Registration Number: NCT00639756

Locations: 🇪🇸
Renal Unit, Mateo Orfila Hospital, Menorca, Balearic Islands, Spain

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