Allopurinol

Generic Name: Allopurinol

Brand Names: Aloprim, Zyloprim

Drug Type: Small Molecule

Chemical Formula: C_₅H_₄N_₄O

CAS Number: 315-30-0

Unique Ingredient Identifier: 63CZ7GJN5I

Background: Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals .
...

Indication: Allopurinol is indicated in :

1) the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
...

Associated Conditions: Hyperuricemia, Primary Gout, Recurrent calcium oxalate calculi, Secondary gout, Calcium oxalate calculi Renal Calculi

Associated Therapies: -

Clinical Trials

Rasburicase (Fasturtec) Registration Trial

Phase 3

Terminated

Conditions: Hyperuricemia

Interventions: Drug: Allopurinol
Drug: Rasburicase

First Posted Date: 2008-02-05

Last Posted Date: 2014-05-08

Lead Sponsor: Sanofi

Target Recruit Count: 10

Registration Number: NCT00607152

Locations: 🇨🇳
Sanofi-Aventis Administrative Office, Shanghai, China

T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer

Phase 1

Completed

Conditions: Leukemia
Multiple Myeloma
Lymphoma
Plasma Cell Neoplasm
Myelodysplastic Syndromes

Interventions: Biological: umbilical cord blood transplantation
Drug: Allopurinol
Drug: fludarabine phosphate
Drug: Cyclophosphamide
Radiation: Total body irradiation
Biological: Treg infusion
Drug: Sirolimus

First Posted Date: 2008-01-28

Last Posted Date: 2017-12-02

Lead Sponsor: Masonic Cancer Center, University of Minnesota

Target Recruit Count: 41

Registration Number: NCT00602693

Locations: 🇺🇸
Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota, United States

Efficacy of Allopurinol and Dypiridamole in Acute Mania

Phase 4

Completed

Conditions: Mania

Interventions: Drug: Allopurinol
Drug: Placebo
Drug: Dipyridamole

First Posted Date: 2007-11-19

Last Posted Date: 2016-08-16

Lead Sponsor: Hospital Espirita de Porto Alegre

Target Recruit Count: 180

Registration Number: NCT00560079

Locations: 🇧🇷
Hospital Espirita de Porto Alegre, Porto Alegre, RS, Brazil

Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant

First Posted Date: 2007-08-08

Last Posted Date: 2017-05-25

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 46

Registration Number: NCT00513474

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

APEX Study: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients With Cardiac Syndrome X

Phase 4

Completed

Conditions: Syndrome X

Interventions: Drug: placebo
Drug: allopurinol

First Posted Date: 2007-08-07

Last Posted Date: 2010-06-28

Lead Sponsor: University of Dundee

Target Recruit Count: 40

Registration Number: NCT00512057

Locations: 🇬🇧
University of Dundee, Dundee, United Kingdom

Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Phase 4

Completed

Conditions: Chronic Heart Failure

First Posted Date: 2007-05-24

Last Posted Date: 2007-05-24

Lead Sponsor: Universita di Verona

Registration Number: NCT00477789

Locations: 🇮🇹
Division of Cardiology, University Hospital of Verona, Verona, Italy

Efficacy and Safety of Oral Febuxostat in Participants With Gout

Phase 3

Completed

Conditions: Gout

Interventions: Drug: Febuxostat
Drug: Allopurinol

First Posted Date: 2007-02-01

Last Posted Date: 2012-02-02

Lead Sponsor: Takeda

Target Recruit Count: 2269

Registration Number: NCT00430248

Antenatal Allopurinol in Intrauterine Growth Restriction

Not Applicable

Conditions: Fetal Growth Retardation

First Posted Date: 2006-06-30

Last Posted Date: 2008-04-28

Lead Sponsor: UMC Utrecht

Target Recruit Count: 50

Registration Number: NCT00346463

Locations: 🇳🇱
Wilhelmina Children's Hospital / UMC Utrecht, Utrecht, Netherlands

Primary Prevention of Hypertension in Obese Adolescents

Phase 2

Completed

Conditions: Obesity
Pre-Hypertension
Hyperuricemia

Interventions: Drug: Placebo
Drug: Allopurinol
Drug: Probenecid

First Posted Date: 2006-02-07

Last Posted Date: 2017-09-14

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 60

Registration Number: NCT00288158

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States

Allopurinol for Renal Transplant Associated Hypertension in Children

Phase 1

Withdrawn

Conditions: Hypertension
Renal Transplant

Interventions: Drug: Placebo
Drug: Allopurinol

First Posted Date: 2006-02-07

Last Posted Date: 2017-09-13

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Registration Number: NCT00288171

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States

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