MedPath

Indinavir

Generic Name
Indinavir
Brand Names
Crixivan
Drug Type
Small Molecule
Chemical Formula
C36H47N5O4
CAS Number
150378-17-9
Unique Ingredient Identifier
9MG78X43ZT
Background

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]

Indication

Indinavir is an antiretroviral drug for the treatment of HIV infection.

Associated Conditions
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Associated Therapies
-

Safety and Tolerance of Indinavir Plus Ritonavir in HIV-Positive Patients Failing Therapy With Amprenavir, Nelfinavir, or Saquinavir

Phase 1
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
50
Registration Number
NCT00001133
Locations
🇺🇸

USC CRS, Los Angeles, California, United States

🇺🇸

Ucsf Aids Crs, San Francisco, California, United States

🇺🇸

Alabama Therapeutics CRS, Birmingham, Alabama, United States

and more 4 locations

Virologic and Immunologic Activity of Continued Lamivudine (3TC) vs Delavirdine (DLV) in Combination With Indinavir (IDV) and Zidovudine (ZDV) or Stavudine (d4T) in 3TC-Experienced Subjects

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2013-07-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
300
Registration Number
NCT00000882
Locations
🇺🇸

State of MD Div of Corrections / Johns Hopkins Univ Hosp, Baltimore, Maryland, United States

🇺🇸

Northwestern Univ Med School, Chicago, Illinois, United States

🇺🇸

Cook County Hosp, Chicago, Illinois, United States

and more 28 locations

Effectiveness of Anti-HIV Drugs in Patients Who Have Not Received Previous Anti-HIV Drugs During Different Stages of HIV Infection

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2011-03-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
24
Registration Number
NCT00006443
Locations
🇺🇸

Michael S. Saag, Birmingham, Alabama, United States

A Study of the Safety and Effectiveness of Hydroxyurea in Patients on Potent Antiretroviral Therapy and Who Have Less Than 200 Copies/ml of HIV RNA in Their Blood

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
399
Registration Number
NCT00000916
Locations
🇺🇸

Harbor-UCLA Med. Ctr. CRS, Torrance, California, United States

🇺🇸

Weiss Memorial Hosp., Chicago, Illinois, United States

🇺🇸

Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, United States

and more 31 locations

A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
475
Registration Number
NCT00000912
Locations
🇺🇸

USC Univ Hosp & Ambulatory Hlth Care Ctr / USC Med Ctr, Los Angeles, California, United States

🇺🇸

Emory Univ, Atlanta, Georgia, United States

🇺🇸

UCLA CARE Ctr, Los Angeles, California, United States

and more 42 locations

Controlled Clinical Trial of Antiviral Cytotoxic T Lymphocyte (CTL) Infusion Following Combination Antiretroviral Drug Therapy for Asymptomatic HIV-1 Infection

Not Applicable
Terminated
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2016-12-14
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
16
Registration Number
NCT00000875
Locations
🇺🇸

The Ctr For Blood Research Inc, Boston, Massachusetts, United States

Comparison of New Anti-HIV Drug Combinations in HIV-Infected Children Who Have Taken Anti-HIV Drugs

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
240
Registration Number
NCT00001083
Locations
🇺🇸

Harbor - UCLA Med Ctr / UCLA School of Medicine, Los Angeles, California, United States

🇺🇸

Univ of Miami (Pediatric), Miami, Florida, United States

🇺🇸

North Shore Univ Hosp, Great Neck, New York, United States

and more 58 locations

A Study to Evaluate the Safety and Tolerance of Combination Anti-HIV Drug Therapy (Indinavir, Lamivudine, and Zidovudine) in HIV-Positive Pregnant Women and Their Infants

Phase 1
Completed
Conditions
HIV Infections
Pregnancy
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
24
Registration Number
NCT00000944
Locations
🇺🇸

Montefiore Med. Ctr. - AECOM, Bronx, New York, United States

🇺🇸

Jacobi Med. Ctr., Bronx, New York, United States

🇺🇸

HMS - Children's Hosp. Boston, Div. of Infectious Diseases, Boston, Massachusetts, United States

and more 1 locations

Study of How Indinavir (an Anti-HIV Drug) and Rifabutin (a Drug Used to Treat MAC, an HIV-Associated Disease) Interact in HIV-Positive and HIV-Negative Adults

Phase 1
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
31
Registration Number
NCT00000877
Locations
🇺🇸

Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States

🇺🇸

Univ of Southern California / LA County USC Med Cntr, Los Angeles, California, United States

🇺🇸

Univ of Miami School of Medicine, Miami, Florida, United States

and more 5 locations
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